Daniel Langner

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Cyber-physical systems react on events reported by sensors and interact with objects of the real world according to their current state and their view of the world. This view is naturally represented by a model which is continuously analysed and updated at runtime. Model analyses should be ideally concise and efficient, requiring well-founded,(More)
A method for digitally reducing thermal plume data obtained from a Bendix Thermal Mapper is presented. This method includes a distortion removal technique and the calculation of apparent blackbody temperature from the scanner's output film. This method is illustrated using data obtained with a Bendix scanner over the Surry Station nuclear power generating(More)
Substitution of A1-glycine of insulin by L-amino acids yields in analogues with low biological activity. With D-amino acids in A1 biological activity is essentially retained. The influence of aliphatic, aromatic, acidic and basic alpha-D-amino acids as well as omega-amino acids in A1 on the biological effects in different test systems is studied and(More)
To make distributed systems resource aware and adaptive, they can be modeled as self-adaptive systems. Such systems have a view of their own state and context, which can be represented by a model that is continuously updated and analyzed at runtime. However, such analyses need to be concise and efficient to allow large models and high adaptation rates. To(More)
Neutron coincidence counting techniques are widely used for nuclear safeguards inspection. They are based on the detection of time correlated neutrons created from spontaneous or induced fission of plutonium and some other actinides. IAEA inspectors are trained to know and to use this technique, but it is not easy to illustrate and explain the basics of the(More)
Stepwise Edman degradation of the insulin B chain is achieved after reversible protection of the amino groups in A1 and B29 with the acid-stable methylsulfonylethyloxycarbonyl residue. Condensation of the protected N-terminal tetrapeptide of insulin-like growth factor I with the degraded insulin yields an hybrid insulin whose synthesis and biological(More)
[AlaB5]Insulin as well as a hybrid analogue of insulin and "insulin-like growth factor" (IGF-I), in which the N-terminal amino-acid sequence H-Phe-Val-Asn-Gln- of the B-chain has been replaced by the tripeptide H-Gly-Pro-Glu-of IGF-I, have been prepared by the partial-synthetic route. Their biological activity in vivo has been compared with that of other(More)
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