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Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16% of all breast cancers. Here we show in 104 TNBC cases that at the time of diagnosis these cancers exhibit a wide and continuous spectrum of genomic evolution, with some having(More)
Loss of heterozygosity (LOH) and copy number alteration (CNA) feature prominently in the somatic genomic landscape of tumors. As such, karyotypic aberrations in cancer genomes have been studied extensively to discover novel oncogenes and tumor-suppressor genes. Advances in sequencing technology have enabled the cost-effective detection of tumor genome and(More)
OBJECTIVE To assess the public's knowledge about depression, attitudes toward treatments for depression, perceived causal factors for depression, and reported prognoses of depression, overall and by sex. METHODS We conducted a cross-sectional telephone survey in Alberta between February and June 2006. We used a random phone number selection procedure to(More)
  • D W Lai
  • 1999
This study explores the impact of violence exposure on the mental health of the adolescents in a rural small town. A structured questionnaire was used to survey 347 adolescents. Violence experienced and witnessed by the adolescents at school, in the neighbourhood, and at home was measured. Mental health was represented by the psychiatric symptoms,(More)
RNA-RNA interactions are fast emerging as a major functional component in many newly discovered non-coding RNAs. Basepairing is believed to be a major contributor to the stability of these intermolecular interactions, much like intramolecular basepairs formed in RNA secondary structure. As such, using algorithms similar to those for predicting RNA secondary(More)
OBJECTIVES To identify gender specific demographic, clinical, knowledge and attitudinal factors associated with stigma related to depression. METHODS Data were collected between February and June 2006 in a probability sampled population-based survey of 3047 adults in Alberta, Canada. Measures included a depression stigma scale. Correlates of stigma were(More)
Visually examining RNA structures can greatly aid in understanding their potential functional roles and in evaluating the performance of structure prediction algorithms. As many functional roles of RNA structures can already be studied given the secondary structure of the RNA, various methods have been devised for visualizing RNA secondary structures. Most(More)
OBJECTIVES To estimate and compare the percentages of personal stigma by levels of depression literacy and exposure to persons with depression, overall and by gender. METHODS Data were collected in a probability sampled population-based survey of 3047 adults in Alberta, Canada. Measures included a 9-item depression stigma scale. Personal stigma was(More)
The expression of genes, both coding and noncoding, can be significantly influenced by RNA structural features of their corresponding transcripts. There is by now mounting experimental and some theoretical evidence that structure formation in vivo starts during transcription and that this cotranscriptional folding determines the functional RNA structural(More)
ABSTRACTOBJECTIVEThis study aimed to describe the level of complementary and alternative medicine (CAM) use and the factors associated with CAM use among Chinese and white Canadians.DESIGNA cross-sectional telephone survey conducted in English, Cantonese, and Mandarin.SETTINGCalgary, Alta.PARTICIPANTSChinese and white residents of Calgary aged 18 or(More)