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Luminal Progenitors Restrict Their Lineage Potential during Mammary Gland Development
The hierarchical relationships between stem cells and progenitors that guide mammary gland morphogenesis are still poorly defined. While multipotent basal stem cells have been found within theExpand
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Notch Lineages and Activity in Intestinal Stem Cells Determined by a New Set of Knock-In Mice
The conserved role of Notch signaling in controlling intestinal cell fate specification and homeostasis has been extensively studied. Nevertheless, the precise identity of the cells in which NotchExpand
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Notch3 marks clonogenic mammary luminal progenitor cells in vivo
Notch3 expression characterizes a highly clonogenic and transiently quiescent luminal progenitor population in the mammary gland, the expansion of which is restricted by Notch3 receptor activity.
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Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung
Prevailing dogma holds that cell–cell communication through Notch ligands and receptors determines binary cell fate decisions during progenitor cell divisions, with differentiated lineages remainingExpand
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Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages
Notch signalling is implicated in stem and progenitor cell fate control in numerous organs. Using conditional in vivo genetic labelling we traced the fate of cells expressing the Notch2 receptorExpand
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Immunohistochemical expression of Notch signaling in the lining epithelium of periapical cysts.
INTRODUCTION In this study we evaluated the immunohistochemical expression of the receptors Notch 1 and Notch 2, the ligand Delta 1, and the transcription factors HES 1 and HES 5 in the epithelium ofExpand
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P53 mutations in stromal fibroblasts sensitize tumors against chemotherapy
The efficacy of chemotherapy is usually viewed as the outcome of cancer‐cell‐autonomous processes while the contribution of stroma is being overseen. Here we show that p53 mutations in stromalExpand
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Evaluation of Re and (99m)Tc complexes of 2-(4'-aminophenyl)benzothiazole as potential breast cancer radiopharmaceuticals.
The synthesis of M(I)(CO)(3)(NNO) (M = Re, (99m)Tc) complexes conjugated to the antitumor agent 2-(4'-aminophenyl)benzothiazole and to its 6-methyl derivative, as well as their in vitro and in vivoExpand
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Essential role of p21/waf1 in the mediation of the anti-proliferative effects of GHRH antagonist JMR-132.
GHRH, besides its neuroendocrine action in controlling the release of GH from the pituitary, stimulates the growth of various cancers in vivo and in vitro by direct mechanism(s). However, theExpand
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A whole genome sequencing association study of severe, uncontrolled asthma
Introduction: Genome-wide association studies (GWAS) have discovered >30 loci associated with asthma risk. Despite the characterization of asthma as a heterogeneous disorder, most GWAS evaluateExpand
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