Daniel L. Morris

Michael A Debord1
Caroline M Davis1
1Michael A Debord
1Caroline M Davis
1Stephanie M Bilinovich
1Ram B Khattri
1Andrew J Caras
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Selective hits for the glutaredoxin ortholog of Brucella melitensis are determined using STD NMR and verified by trNOE and (15)N-HSQC titration. The most promising hit, RK207, was docked into the target molecule using a scoring function to compare simulated poses to experimental data. After elucidating possible poses, the hit was further optimized into the(More)
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