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nor any of their employees, makes any w arranty, express or implied, or assumes any legal responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed , or represents that its use would not infringe privately owned rights. Reference herein to any speciic commercial product, process, or service by(More)
density ␳) that satisfies an advection equation of the form We present a numerical method for computing solutions of the incompressible Euler or Navier–Stokes equations when a principal ␳ t ϩ ٌ и (␳u) ϭ 0, (1) feature of the flow is the presence of an interface between two fluids with different fluid properties. The method is based on a where u denotes the(More)
22 break symmetry in certain situations and does not generalize to 3-D unstructured meshes. A 3-D unsplit scheme is therefore highly desirable, but remains a formidable task on unstructured meshes. We have currently pursued simpler approaches, such as generalized splitting and Runge Kutta schemes, but fully unsplit 3-D schemes will be the subject of future(More)
The overall peroxidation activity in brain tissue by region from patients with Alzheimer's disease (AD) and age-matched controls was determined employing the thiobarbituric acid-reactive substances (TBARS) assay, a measure of lipid peroxidation, followed by a determination the activities of the antioxidant enzymes Cu/Zn superoxide dismutase (SOD),(More)
Apoptosis, or programmed cell death, has been proposed as a mechanism of neuropathology in Alzheimer's disease (AD). Activation of immediate early genes (IEG) c-jun and c-fos appears to be required for the initiation of apoptosis. Furthermore, the expression of c-jun is induced in cultured neurons that undergo beta-amyloid-mediated apoptosis suggesting a(More)
Isolated mitochondria from rat livers of various ages show a gradual decline in the rate of inner membrane-matrix protein synthesis with advancing age of the animal. Rats at 112-120 weeks synthesize these proteins at only 40% of the rate of 2-8-week-old animals. The initial rates of incorporation of label were 145 cpm/mg/minute for the "old" animals, and(More)
We present an alghorithm for the solution of compressible, reacting flow problems in which burned and unburned fluids are ther-modynamically distinct and separated by a thin flame. We use a higher-order, adap-ti ve Godunov method for the fluid dynamics and the motion of the flame front normal to itself, and a thermodynamically consistent representation of(More)
We have developed a new modeling capability to study the behavior of pulse combustors. Our approach is based on the use of higher-order Godunov methods combined with adaptive strategies to focus computational eeort where it is required and a Cartesian grid formulation for modeling realistic engineering geome-tries. The model computes quasi-one-dimensional,(More)