Daniel L. Lustgarten

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We have studied 19 S107 heavy chain variable region gene (VH11)-encoded monoclonal antibodies from NZBWF1 mice. These studies show that a single VH gene can encode both antibodies to foreign antigens (anti-phosphorylcholine) and to self antigens (anti-double-stranded DNA) in the same animal. All of the anti-DNA antibodies contain many somatic mutations(More)
BACKGROUND It has been proposed that sequential mapping of dominant frequency (DF) and complex fractionated atrial electro-grams (CFAE) can identify target sites for ablation of atrial fibril-lation (AF). These mapping strategies are valid only if DF and CFAE are temporally stable on the timescale of the mapping procedure. We postulate that DF and CFAE are(More)
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