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Recommending news articles has become a promising research direction as the Internet provides fast access to real-time information from multiple sources around the world. Traditional news recommendation systems strive to adapt their services to individual users by virtue of both user and news content information. However, the latent relationships among(More)
INTRODUCTION Heart rate variability (HRV) reflects autonomic nervous system tone as well as the overall health of the baroreflex system. We hypothesized that loss of complexity in HRV upon intensive care unit (ICU) admission would be associated with unsuccessful early resuscitation of sepsis. METHODS We prospectively enrolled patients admitted to ICUs(More)
In this paper, through the use of two vignettes, we present a viewpoint on the concepts of `space' and `place' in an computing context. The first vignette is about a Technicians' Room, where the computer support staff and network infrastructure of a school are located. Although the room's purpose is to provide computing services and technical support to the(More)
BACKGROUND Left ventricular diastolic dysfunction is common in patients with severe sepsis or septic shock, but the best approach to categorization is unknown. We assessed the association of common measures of diastolic function with clinical outcomes and tested the utility of a simplified definition of diastolic dysfunction against the American Society of(More)
Sepsis is a devastating condition that is generally treated as a single disease. Identification of meaningfully distinct clusters may improve research, treatment and prognostication among septic patients. We therefore sought to identify clusters among patients with severe sepsis or septic shock. We retrospectively studied all patients with severe sepsis or(More)
OBJECTIVE The Sequential Organ Failure Assessment (SOFA) score, a measure of multiple-organ dysfunction syndrome, is used to predict mortality in critically ill patients by assigning equally weighted scores across 6 different organ systems. We hypothesized that specific organ systems would have a greater association with mortality than others. DESIGN We(More)
BACKGROUND AND OBJECTIVE Assessment of oxygenation in patients with community-acquired pneumonia is critical for treatment. The accuracy of percutaneous oxygen saturation (SpO2 ) determined by pulse oximetry is uncertain, and it has limited value in patients receiving supplemental oxygen. We hypothesized that calculation of partial arterial oxygen(More)
We have identified and characterized a monoclonal antibody, F2-P3E3, that recognizes a Caenorhabditis elegans apoptotic epitope expressed within phagocytic cells, which is conserved in four other nematode species. In C. elegans, F2-P3E3 staining requires both programmed cell death and phagocytosis. We show that the F2-P3E3 epitope is expressed within(More)