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  • Richard M Goldberg, Daniel J. Sargent, +6 authors Steven Robert Alberts
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2004
  • PURPOSE Three agents with differing mechanisms of action are available for treatment of advanced colorectal cancer: fluorouracil, irinotecan, and oxaliplatin. In this study, we compared the activityExpand
  • Christine M. Ribic, Daniel J. Sargent, +10 authors Steven Gallinger
  • Medicine
  • The New England journal of medicine
  • 2003 (First Publication: 17 July 2003)
  • BACKGROUND Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish them from microsatellite-stable tumors. We investigated the usefulnessExpand
  • James W. Fleshman, Megan E. Branda, +22 authors Heidi Nelson
  • Medicine
  • JAMA
  • 2015 (First Publication: 6 October 2015)
  • IMPORTANCE Evidence about the efficacy of laparoscopic resection of rectal cancer is incomplete, particularly for patients with more advanced-stage disease. OBJECTIVE To determine whetherExpand
  • Scott Kopetz, George J. Chang, +7 authors Robert R McWilliams
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2009 (First Publication: 1 August 2009)
  • PURPOSE Fluorouracil/leucovorin as the sole therapy for metastatic colorectal cancer (CRC) provides an overall survival of 8 to 12 months. With an increase in surgical resections of metastaticExpand
  • Daniel J. Sargent, Silvia Marsoni, +14 authors Steven Gallinger
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2010 (First Publication: 10 July 2010)
  • PURPOSE Prior reports have indicated that patients with colon cancer who demonstrate high-level microsatellite instability (MSI-H) or defective DNA mismatch repair (dMMR) have improved survival andExpand
  • M. Farnell, R. Pearson, +5 authors D. Sargent
  • Medicine
  • Surgery
  • 2005 (First Publication: 1 October 2005)
  • BACKGROUND To compare operative morbidity, mortality, quality of life, and survival after pancreatoduodenectomy (PD) versus pancreatoduodenectomy with extended lymphadenectomy (PD/ELND) in patientsExpand