• Publications
  • Influence
A direct and efficient total synthesis of the tubulin-binding agents ceratamine A and B; use of IBX for a remarkable heterocycle dehydrogenation.
The total synthesis of the tubulin-binding agents ceratamine A and B is reported, along with des-methyl analogs, via a synthetic route that is high-yielding and operationally efficient. The syntheticExpand
Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors.
TLDR
The chemical features of these molecules that are important for both potency and selectivity on Hα4β2 nAChRs are described, through structure-activity relationship (SAR) studies. Expand
Synthesis of functional "top-half" partial structures of azinomycin a and B.
The design and synthesis of a detailed series of functional "top-half" substructures of azinomycin A and B is described.
Structure elucidation of phase I metabolites of the microtubule perturbagens: ceratamines A and B.
The heterocyclic alkaloids, ceratamines A and B, are isolates from a marine Pseudoceratina sp. sponge. They behave as antimitotic agents, with IC50 values in the low micromolar range. The mechanismExpand
Total Synthesis of Ceratamine A & B and Synthesis of Negative Allosteric Modulators of Neuronal Nicotinic Acetylcholine Receptors
.............................................................................................................................. ii DedicationExpand