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Temporally precise labeling and control of neuromodulatory circuits in the mammalian brain
Few tools exist to visualize and manipulate neurons that are targets of neuromodulators. We present iTango, a light- and ligand-gated gene expression system based on a light-inducible split tobacco… Expand
Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.
- B. Melillo, Shuaiyi Liang, +11 authors A. Smith
- Biology, Medicine
- ACS medicinal chemistry letters
- 19 January 2016
The optimization, based on computational, thermodynamic, and crystallographic data, of a series of small-molecule ligands of the Phe43 cavity of the envelope glycoprotein gp120 of human… Expand
Shining light on neuromodulator function with iTango, a new reporting system of ligand-receptor interactions