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The discovery of artemisinin more than 30 years ago provided a completely new antimalarial structural prototype; that is, a molecule with a pharmacophoric peroxide bond in a unique 1,2,4-trioxane heterocycle. Available evidence suggests that artemisinin and related peroxidic antimalarial drugs exert their parasiticidal activity subsequent to reductive(More)
Transgenic APP23 mice expressing human APP(751) with the K670N/M671L mutation, were compared at ages 3, 18 or 25 months to non-transgenic littermates in passive avoidance and in a small and large Morris maze. The task in the smaller pool habituated their flight response to the platform. Impairments in passive avoidance and small pool performance in APP23(More)
According to a recent survey, 16% of all Swiss companies use an e-commerce solution to sell their products [15]. On the other hand, most companies in Switzerland are unfamiliar with the use of the Internet for purchasing and procurement processes and especially for online buying. This paper discusses the new requirements for procurement and shows the new(More)
According to a recent survey, 16% of all Swiss companies use an e-commerce solution to sell their products [15]. On the other hand, most companies in Switzerland are unfamiliar with the use of the Internet for purchasing and procurement processes and especially for online buying. This paper discusses the new requirements for procurement and shows the new(More)
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