Daniel Hsien-Wen Su

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OBJECTIVE Dengue fever causes numerous systemic manifestations, including maculopathy, with loss of vision. This study sought to determine the prevalence of dengue maculopathy in patients hospitalized with dengue fever. DESIGN Cross-sectional observational study in which consecutive patients hospitalized with dengue fever during a dengue epidemic were(More)
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant(More)
PURPOSE To examine the association between central corneal thickness (CCT) and potential systemic and ocular factors affecting CCT in an Asian population. DESIGN Population-based cross-sectional study. METHODS A total of 3,280 (78.7% response) adults aged 40 to 80 years of Malay ethnicity living in Singapore underwent a standardized interview and ocular(More)
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European(More)
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease(More)
IMPORTANCE Selective laser trabeculoplasty (SLT) should be explored as a therapeutic option in eyes with angle closure. OBJECTIVE To assess the intraocular pressure (IOP)-lowering efficacy of SLT in eyes with primary angle closure (PAC) and PAC glaucoma (PACG). DESIGN, SETTING, AND PARTICIPANTS Randomized clinical trial at tertiary eye care institutions(More)
PURPOSE To examine the relationship of diabetes and hyperglycemia with central corneal thickness (CCT) in Malay adults in Singapore. DESIGN Population-based cross-sectional study. PARTICIPANTS Three thousand two hundred eighty Malay adults ages 40-80 years living in Singapore. METHODS The study population was selected using an age-stratified random(More)
OBJECTIVE To assess the value of enhanced depth imaging optical coherence tomography (EDI OCT) in diagnosing and evaluating optic nerve head drusen (ONHD) compared with conventional diagnostic methods. DESIGN Prospective, comparative, cross-sectional study. PARTICIPANTS Thirty-four patients with clinically visible or suspected ONHD in either eye based(More)
OBJECTIVE To compare the performance of 10-2 versus 24-2 visual fields (VFs) in detecting progression of initial parafoveal scotoma (IPFS) in glaucomatous eyes. DESIGN Retrospective, observational study. PARTICIPANTS Glaucoma patients with the following criteria: (1) an IPFS (≥ 3 adjacent points with P<0.05 within the central 10° degrees of fixation, 1(More)
PURPOSE To assess factors associated with focal lamina cribrosa (LC) defects in glaucoma. METHODS Serial enhanced depth imaging (EDI) optical coherence tomography (OCT) B-scans of the optic nerve head were obtained from glaucoma patients. EDI OCT scans were reviewed for focal LC defects (laminar holes or disinsertions). Evaluated clinical factors included(More)