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Proteomic studies have addressed the composition of plant chloroplast ribosomes and 70S ribosomes from the unicellular organism Chlamydomonas reinhardtii But comprehensive characterization of cytoplasmic 80S ribosomes from higher plants has been lacking. We have used two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) to analyse the(More)
PREFACE This is an independent report of the In Vitro Acute Toxicity Peer Review Panel (" Panel ") The ICCVAM and the Acute Toxicity Working Group (ATWG) will consider the Panel report, along with public comments, to prepare final test method recommendations for U.S. Federal agencies. ICCVAM test method recommendations will be forwarded to U.S. Federal(More)
Federal highway grants to states appear to boost economic activity in the short and medium term. The short-term effects appear to be due largely to increases in aggregate demand. Medium-term effects apparently reflect the increased productive capacity brought by improved roads. Overall, each dollar of federal highway grants received by a state raises that(More)
Identifying what people do in the home can both inform ubiquitous computing application design decisions and provide training data to the machine learning algorithms used in their implementation. This paper describes an unsupervised technique in which contextual information gathered by ubiquitous sensors is used to help users label a multitude of anonymous(More)
Microbial virulence is a complex and often multifactorial phenotype, intricately linked to a pathogen's evolutionary trajectory. Toxicity, the ability to destroy host cell membranes, and adhesion, the ability to adhere to human tissues, are the major virulence factors of many bacterial pathogens, including Staphylococcus aureus. Here, we assayed the(More)
Rating how well a routine activity is performed can be valuable in a variety of domains. Making the rating inexpensive and credible is a key aspect of the problem. We formalize the problem as MAP estimation in HMMs where the incoming trace needs repair. We present polynomial time algorithms for computing minimal repairs with maximal likelihood for HMMs,(More)
In-home health assessment of elders is often accomplished with the help of caregivers, usually family and friends. When formal support is necessary, it is commonly provided by case managers, professionals who visit the home to assess the mental and physical status of the elder, or " client. " In an effort to understand how ADLs are collected, we performed(More)
In this paper, we describe " The Activities of Daily Living Study, " a two-phased formative study designed to examine the work practices of professionals who perform in-home monitoring of elders' activities of daily living (ADLs). Supporting elderly adults' preference to live independently at home, i.e., to age in place, can forestall the transition to(More)