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BACKGROUND Evolutionarily conserved sequences likely have biological function. METHODS To determine whether variation in conserved sequences in non-coding DNA contributes to risk for human disease, we studied six conserved non-coding elements in the Th2 cytokine cluster on human chromosome 5q31 in a large Hutterite pedigree and in samples of outbred(More)
When the classical chi(2) goodness-of-fit test for Hardy-Weinberg (HW) equilibrium is used on samples with related individuals, the type I error can be greatly inflated. In particular the test is inappropriate in population isolates where the individuals are related through multiple lines of descent. In this article, we propose a new test for HW (the QL-HW(More)
From a total of 19 papers submitted 4 full papers, 6 posters and 2 demos were accepted. This volume gathers together all the 12 papers accepted at Models@run.time 09. After the workshop, a summary of the workshop will be published to complement these proceedings. We would like to thank a number of people who contributed to this event, especially the members(More)
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