Daniel Hürlimann

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We consider a problem faced by train companies: How can trains be assigned to satisfy scheduled routes in a cost efficient way? Currently, many railway companies create solutions by hand, a timeconsuming task which is too slow for interaction with the schedule creators. Further, it is difficult to measure how efficient the manual solutions are. We consider(More)
For Trypanosoma brucei arginine and lysine are essential amino acids and therefore have to be imported from the host. Heterologous expression in Saccharomyces cerevisiae mutants identified cationic amino acid transporters among members of the T. brucei AAAP (amino acid/auxin permease) family. TbAAT5-3 showed high affinity arginine uptake (Km 3.6 ± 0.4 μM)(More)
This paper describes how the combined use of OpenTimeTable, a schedule analysis program, and OpenTrack, a railroad network simulation program, can be used to help develop more robust timetables. The paper describes how these programs and additional statistical analysis was used to help identify causes of delay and evaluate solutions for reducing this delay(More)
The role of protein kinase C (PKC) and their isoforms in cell growth regulation remains elusive. Here we showed that in cultured human vascular smooth muscle cells (SMC), the PKC stimulator phorbol 12-myristate 13-acetate (PMA) inhibited [(3)H]thymidine incorporation in response to the growth factor PDGF associated with downregulation of PDGFbeta (but not(More)
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