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Activating mutations in the epidermal growth factor receptor (EGFR) tyrosine kinase domain determine responsiveness to EGFR tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer (NSCLC). The modulation of transcriptional pathways by mutant EGFR signaling is not fully understood. Previously, we and others identified a single base(More)
OBJECTIVE Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity. DESIGN By utilising large scale transcriptome sequencing of(More)
Mol (complement receptor type 3, CR3; CDllb/CD18) is an adhesion-promoting human leuko-cyte surface membrane heterodimer (alpha subunit 155 kD [CDllb] noncovalently linked to a beta subunit of 95 kD [CDI8]). The complete amino acid sequence deduced from cDNA of the human alpha subunit is reported. The protein consists of 1,136 amino acids with a long(More)
leukemogenesis hematopoietic stem cells in a transgenic model of BCR-ABL Inducible chronic phase of myeloid leukemia with expansion of (795 articles) Oncogenes and Tumor Suppressors (4217 articles) Neoplasia (3094 articles) Hematopoiesis and Stem Cells Articles on similar topics can be found in the following Blood collections Information about subscriptions(More)
DNA methylation was first described almost a century ago; however, the rules governing its establishment and maintenance remain elusive. Here we present data demonstrating that active transcription regulates levels of genomic methylation. We identify a novel RNA arising from the CEBPA gene locus that is critical in regulating the local DNA methylation(More)
CCAAT/enhancer binding protein ␣ (C/EBP␣) is an integral factor in the granulocytic developmental pathway, as myeloblasts from C/EBP␣-null mice exhibit an early block in differentiation. Since mice deficient for known C/EBP␣ target genes do not exhibit the same block in granulocyte maturation, we sought to identify additional C/EBP␣ target genes essential(More)
BACKGROUND Epidermal growth factor receptor (EGFR) mutations are present in the majority of patients with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib or erlotinib. These EGFR-dependent tumors eventually become TKI resistant, and the common secondary T790M mutation accounts for half the tumors with(More)
In blood, the transcription factor C/EBPa is essential for myeloid differentiation and has been implicated in regulating self-renewal of fetal liver haematopoietic stem cells (HSCs). However, its function in adult HSCs has remained unknown. Here, using an inducible knockout model we found that C/EBPa-deficient adult HSCs underwent a pronounced increase in(More)
The t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-initiating transcription factor that interferes with RUNX1 function. The result of this interference is a block in differentiation and, finally, the development of acute myeloid leukemia(More)