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HSP90 at the hub of protein homeostasis: emerging mechanistic insights
Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins (known as clients). Clients are enriched in signal transducers,Expand
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A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates
Translesion synthesis (TLS) by Y-family DNA polymerases is a chief mechanism of DNA damage tolerance. Such TLS can be accurate or error-prone, as it is for bypass of a cyclobutane pyrimidine dimer byExpand
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Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation
Exploiting Variation Molecular chaperones help newly synthesized proteins fold, protecting the macromolecular machinery of the cell from various stresses; for example, the highly conserved heat shockExpand
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Prions are a common mechanism for phenotypic inheritance in wild yeasts
The self-templating conformations of yeast prion proteins act as epigenetic elements of inheritance. Yeast prions might provide a mechanism for generating heritable phenotypic diversity that promotesExpand
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UmuD and RecA directly modulate the mutagenic potential of the Y family DNA polymerase DinB.
DinB is the only translesion Y family DNA polymerase conserved among bacteria, archaea, and eukaryotes. DinB and its orthologs possess a specialized lesion bypass function but also displayExpand
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Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms.
Changing a single nucleotide in a genome can have profound consequences under some conditions, but the same change can have no consequences under others. Indeed, organisms can be surprisingly robustExpand
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Y-family DNA polymerases in Escherichia coli.
The observation that mutations in the Escherichia coli genes umuC+ and umuD+ abolish mutagenesis induced by UV light strongly supported the counterintuitive notion that such mutagenesis is an activeExpand
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Characterization of Escherichia coli translesion synthesis polymerases and their accessory factors.
Members of the Y family of DNA polymerases are specialized to replicate lesion-containing DNA. However, they lack 3'-5' exonuclease activity and have reduced fidelity compared to replicativeExpand
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A DinB variant reveals diverse physiological consequences of incomplete TLS extension by a Y-family DNA polymerase
The only Y-family DNA polymerase conserved among all domains of life, DinB and its mammalian ortholog pol κ, catalyzes proficient bypass of damaged DNA in translesion synthesis (TLS). Y-family DNAExpand
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Y‐family DNA polymerases respond to DNA damage‐independent inhibition of replication fork progression
In Escherichia coli, the Y‐family DNA polymerases Pol IV (DinB) and Pol V (UmuD2′C) enhance cell survival upon DNA damage by bypassing replication‐blocking DNA lesions. We report a unique functionExpand
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