Daniel F Tardiff

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A Yeast Model of FUS/TLS-Dependent Cytotoxicity

Shulin Ju, Daniel F Tardiff, +9 authors Gregory A. Petsko
PLoS biology
2011

FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus,… (More)

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

Chee Yeun Chung, Vikram Khurana, +19 authors Susan Lindquist
Science
2013

The induced pluripotent stem (iPS) cell field holds promise for in vitro disease modeling. However, identifying innate cellular pathologies, particularly for age-related neurodegenerative diseases,… (More)

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.

Linhui Julie Su, Pavan K. Auluck, +16 authors Susan Lindquist
Disease models & mechanisms
2010

alpha-Synuclein (alpha-syn) is a small lipid-binding protein involved in vesicle trafficking whose function is poorly characterized. It is of great interest to human biology and medicine because… (More)

A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional.

Daniel F Tardiff, Scott A. Lacadie, Michael Rosbash
Molecular cell
2006

Recent ChIP experiments indicate that spliceosome assembly and splicing can occur cotranscriptionally in S. cerevisiae. However, only a few genes have been examined, and all have long second exons.… (More)

Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking.

Daniel F Tardiff, Katharine C Abruzzi, Michael Rosbash
Proceedings of the National Academy of Sciences…
2007

To characterize proteins associated with active transcription complexes, we purified RNA polymerase II (pol II) from Saccharomyces cerevisiae after fixing live cells with formaldehyde. The approach… (More)

Arrested yeast splicing complexes indicate stepwise snRNP recruitment during in vivo spliceosome assembly.

Pre-mRNA splicing is catalyzed by the spliceosome, a macromolecular machine dedicated to intron removal and exon ligation. Despite an abundance of in vitro information and a small number of in vivo… (More)

Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms*

Daniel F Tardiff, Michelle L. Tucci, Kim A. Caldwell, Guy A Caldwell, Susan Lindquist
The Journal of biological chemistry
2012

No current therapies target the underlying cellular pathologies of age-related neurodegenerative diseases. Model organisms provide a platform for discovering compounds that protect against the toxic,… (More)

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

Daniel F Tardiff, Nathan T Jui, +11 authors Susan Lindquist
Science
2013

α-Synuclein (α-syn) is a small lipid-binding protein implicated in several neurodegenerative diseases, including Parkinson's disease, whose pathobiology is conserved from yeast to man. There are no… (More)

L30 binds the nascent RPL30 transcript to repress U2 snRNP recruitment.

Sara Macías, Mireia Bragulat, Daniel F Tardiff, Josep Vilardell
Molecular cell
2008

The mechanisms of pre-mRNA splicing regulation are poorly understood. Here we dissect how the Saccharomyces cerevisiae ribosomal L30 protein blocks splicing of its pre-mRNA upon binding a kink-turn… (More)

In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants.

Scott A. Lacadie, Daniel F Tardiff, Sebastián Kadener, Michael Rosbash
Genes & development
2006

Spliceosome assembly in the budding yeast Saccharomyces cerevisiae was recently shown to occur at the site of transcription. However, evidence for cotranscriptional splicing as well as for coupling… (More)

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