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Taxadiene is the first dedicated intermediate in the biosynthetic pathway of the anticancer compound Taxol. Recent studies have taken advantage of heterologous hosts to produce taxadiene and other isoprenoid compounds, and such ventures now offer research opportunities that take advantage of the engineering tools associated with the surrogate host. In this(More)
We present and benchmark an approximate dynamic programming algorithm that is capable of designing near-optimal control policies for time-dependent, finite-horizon energy storage problems, where wind supply, demand and electricity prices may evolve stochastically. We found that the algorithm was able to design storage policies that are within 0.08% of(More)
Taxa-4(5),11(12)-diene is the first dedicated intermediate in the metabolic pathway responsible for synthesizing the anticancer compound Taxol. In this study, the heterologous production of taxadiene was established in and analyzed between K- and B-derived Escherichia coli strains. First, recombinant parameters associated with precursor metabolism (the(More)
—As more renewable, yet volatile, forms of energy like solar and wind are being incorporated into the grid, the problem of finding optimal control policies for energy storage is becoming increasingly important. These sequential decision problems are often modeled as stochastic dynamic programs, but when the state space becomes large, traditional (exact)(More)
INTRODUCTION AND OBJECTIVES An abnormal ankle-braquial index (ABI) has been related to a higher vascular mortality in the general population. People with HIV infection have a higher prevalence of abnormal ABI than general population. Our aim was to study that prevalence in a cohort of patients with HIV chronic infection and associated factors with an(More)
OBJECTIVES To record the experience with use of raltegravir (RTG) for devising highly active antiretroviral therapy (HAART) regimens based on RTG in high vascular risk patients. METHODS A retrospective study was conducted on high vascular risk patients taking RTG. Case was a patient who, at the time raltegravir was started, had ≥ 20% 10-year risk of(More)
BACKGROUND Vascular risk is an important cause of morbidity and mortality in HIV infected patients. AIM To study the value of the ankle-brachial index (ABI) in vascular risk stratification in a cohort of people with HIV infection. PATIENTS AND METHODS Vascular risk was calculated in all the patients that agreed to participate in the study and clinical(More)
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