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Journals and Conferences
Peripheral membrane proteins utilize a variety of mechanisms to attach tightly, and often reversibly, to cellular membranes. The covalent lipid modifications, myristoylation and palmitoylation, are… (More)
The heterotrimeric G protein subunit, alpha(s), can move reversibly from plasma membranes to cytoplasm in response to activation by GPCRs or activating mutations. We examined the importance of the… (More)
G protein-coupled receptor kinases (GRKs) specifically phosphorylate agonist-occupied G protein-coupled receptors at the inner surface of the plasma membrane (PM), leading to receptor… (More)
Mutation of Galpha(q) or Galpha(s) N-terminal contact sites for Gbetagamma resulted in alpha subunits that failed to localize at the plasma membrane or undergo palmitoylation when expressed in HEK293… (More)
Microfluidics devices are well known for their ability to perform complex manipulations on minute samples, but they can also be powerful tools for analyzing large sample volumes.
Heterotrimeric G proteins typically localize at the cytoplasmic face of the plasma membrane where they interact with heptahelical receptors. For G protein alpha subunits, multiple membrane targeting… (More)
A brief description of the theory and methods behind super-resolution fluorescence imaging. Fluorescence imaging 101 When fluorescent moleculesfluorophoresabsorb a photon, they almost always emit a… (More)
It is becoming evident that glia, and astrocytes in particular, are intimately involved in neuronal signaling. Astrocytic modulation of signaling in neurons appears to be mediated by the release of… (More)
Biology is a visually grounded scientific discipline—from the way data is collected and analyzed to the manner in which the results are communicated to others. Visualization methods have advanced… (More)
The combination of environmentally sensitive small organic dyes with single-chain antibodies creates an extendable family of new fluorescent probes.