Filter Results:
- Full text PDF available (5)
Publication Year
1979
2018
- This year (2)
- Last 5 years (4)
- Last 10 years (15)
Publication Type
Co-author
Journals and Conferences
Learn More
- Daniel E. Keyler, Samuel A. Roiko, +6 authors Paul R. Pentel
- Drug metabolism and disposition: the biological…
- 2005
Vaccination against nicotine is being studied as a potential treatment for nicotine dependence. Some of the limitations of vaccination, such as variability in antibody titer and affinity, might be… (More)
- Yoko Hieda, Daniel E. Keyler, +5 authors Paul R. Pentel
- The Journal of pharmacology and experimental…
- 1997
The ability of active immunization to alter nicotine distribution was studied in rats. Animals were immunized with 6-(carboxymethylureido)-(+/-)-nicotine (CMUNic) linked to keyhole limpet hemocyanin… (More)
- Mark G Lesage, Daniel E. Keyler, +4 authors Paul R. Pentel
- Psychopharmacology
- 2005
Immunization of rats against nicotine using a nicotine conjugate vaccine reduces the distribution of nicotine to brain in rats and attenuates some of nicotine's physiological and behavioral effects.… (More)
- Paul R. Pentel, Daniel E. Keyler
- The Journal of pharmacology and experimental…
- 1988
Tricyclic antidepressants are bound extensively to alpha-1-acid glycoprotein (AAG) in serum. It has been suggested that the extent of drug-protein binding may influence the magnitude of… (More)
- Mark G Lesage, Danielle Burroughs, Matthew B Dufek, Daniel E. Keyler, Paul R. Pentel
- Pharmacology Biochemistry and Behavior
- 2004
The objective of the present study was to determine the relative efficacy of nicotine priming and nicotine-paired stimuli in reinstating extinguished NSA in rats. The relative efficacy of different… (More)
- Junran Cao, James D. Belluzzi, Sandra E Loughlin, Daniel E. Keyler, Paul R. Pentel, Frances M. Leslie
- Neuropsychopharmacology
- 2007
We have previously shown that acetaldehyde, a constituent of tobacco smoke, increases nicotine self-administration in adolescent, but not adult, rats. The aim of this study was to determine whether… (More)
- Samuel A. Roiko, Andrew C Harris, Mark G Lesage, Daniel E. Keyler, Paul R. Pentel
- Pharmacology Biochemistry and Behavior
- 2009
Vaccination against nicotine is under investigation as a treatment for tobacco dependence. Passive immunization with nicotine-specific antibodies represents a complementary strategy to vaccination. A… (More)
- Daniel E. Keyler, Yoko Hieda, John V. St. Peter, Paul R. Pentel
- Nicotine & tobacco research : official journal of…
- 1999
Active immunization of rats against nicotine reduces the distribution of a single intravenous dose of nicotine to brain. The current study examined the effects of immunization on the distribution of… (More)
- Andrew C Harris, Christina Mattson, Mark G Lesage, Daniel E. Keyler, Paul R. Pentel
- Pharmacology Biochemistry and Behavior
- 2010
Animal models of tobacco dependence typically rely on parenteral administration of pure nicotine. Models using cigarette smoke inhalation might more accurately simulate nicotine exposure in smokers.… (More)
- Mark G Lesage, Daniel E. Keyler, Paul R. Pentel
- The AAPS Journal
- 2006
In contrast to current pharmacotherapies, immunologic approaches to treating tobacco dependence target the drug itself rather than the brain. This approach involves the use of nicotine-specific… (More)