Daniel Dunham

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PURPOSE The study goals were to (1) determine the proportion of unselected individuals at increased risk for diseases with known genetic components and (2) compare the documentation and quality of risk assessment between a questionnaire, a pedigree interview, and chart review. METHODS Seventy-eight patients seen in a division of internal medicine were(More)
Binding region and link protein were prepared from pig laryngeal cartilage proteoglycans after chondroitinase ABC and trypsin digestion. Experiments on gel chromatography showed the purified binding region to interact reversibly with hyaluronate (HA), and this binding was also shown to be stabilized by native link protein. The trypsin-prepared link protein(More)
BACKGROUND Failing to inform a patient of an abnormal outpatient test result can be a serious error, but little is known about the frequency of such errors or the processes for managing results that may reduce errors. METHODS We conducted a retrospective medical record review of 5434 randomly selected patients aged 50 to 69 years in 19 community-based and(More)
Proteoglycan aggregates of cartilage are stabilized by the formation of a ternary complex between the G1 domain at the N-terminus of the proteoglycan monomer (aggrecan), link protein and hyaluronan polysaccharide. Both the G1 domain and link protein contain similar three-domain structures formed from an immunoglobulin fold and two proteoglycan tandem(More)
The structure of the protein core of the high molecular weight aggregating proteoglycan from pig laryngeal cartilage has been investigated. Mild trypsin digestion of proteoglycan aggregates released a large (Mr approximately equal to 150K) protein-rich fragment that contained the hyaluronate-binding region (Mr 66K). Rotary-shadowing electron microscopy of(More)
Electron microscopy after rotary shadowing and negative staining of the large chondroitin sulphate proteoglycan from rat chondrosarcoma, bovine nasal cartilage and pig laryngeal cartilage demonstrated a unique multidomain structure for the protein core. A main characteristic is a pair of globular domains (diameter 6-8 nm), one of which forms the N-terminal(More)
The interaction of proteoglycan monomers with hyaluronate in cartilage is mediated by a globular binding region at the N-terminus of the proteoglycan monomer; this interaction is stabilized by link protein. Sequences show that both the binding region (27% carbohydrate) and the link protein (6% carbohydrate) contain an immunoglobulin (Ig) fold domain and two(More)
A 48-year-old #{248}ma with a history of porly controlled hypertension presented with shortness of breath . She had a five-yearhistory of hypertension but was otherrhqse in good health until 10 PM On the day of hospital admission when she had paroxysms of cough accompanied by a fever of 38.5#{176}C.The mugh was nonproductive and was 500fl followed b(More)
STATEMENT OF PROBLEM Removable partial denture frameworks are complex castings fabricated from high-shrinkage alloys. This may result in difficulty in achieving accurate fit. PURPOSE The purpose of this study was to evaluate which component(s) of the clasp assembly contact the abutment tooth clinically. MATERIAL AND METHODS New and existing frameworks(More)