Daniel D McKinnon

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Presented here is a cytocompatible covalently adaptable hydrogel uniquely capable of mimicking the complex biophysical properties of native tissue and enabling natural cell functions without matrix degradation. Demonstrated is both the ability to control elastic modulus and stress relaxation time constants by more than an order of magnitude while predicting(More)
Studies focused on understanding the role of matrix biophysical signals on cells, especially those when cells are encapsulated in hydrogels that are locally remodelled, are often complicated by appropriate methods to measure differences between the bulk and local material properties. From this perspective, stress-relaxing materials that allow long-term(More)
Hydrogels with photocleavable units incorporated into the cross-links have provided researchers with the ability to control mechanical properties temporally and study the role of matrix signaling on stem cell function and fate. With a growing interest in dynamically tunable cell culture systems, methods to synthesize photolabile hydrogels from simple(More)
Figure 1. Evolution of the shear elastic modulus of the stoichiometric 8-H:8-AA hydrogel. Fitting these data to Equation 1, the equilibrium modulus, G eq , is 30 kPa unswollen. After swelling, this value declines to ca. 10 kPa, which was previously reported. The data are the open squares and the fit is the solid line.
In a duct-flute such as the recorder, steady-state oscillations are controlled by two parameters, the blowing pressure and the frequency of the acoustic resonator. As in most feedback oscillators, the oscillation amplitude is determined by gain-saturation of the amplifier, and thus it cannot be controlled independently of blowing pressure and frequency(More)
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