Daniel Citterio

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This paper presents an inkjet printing method for the fabrication of entire microfluidic multianalyte chemical sensing devices made from paper suitable for quantitative analysis, requiring only a single printing apparatus. An inkjet printing device is used for the fabrication of three-dimensional hydrophilic microfluidic patterns (550-mum-wide flow(More)
This paper describes a colorimetric sensor array for the discrimination of volatile amines. Analyte discrimination is achieved by combining two functional elements: (1) a "chemical class-selective" single chromogenic sensing dye with selectivity for amines in general, encapsulated into (2) polymer nanoparticles with different polarities. The resulting array(More)
An inkjet-printed microfluidic paper-based analytical device (μPAD) for the detection of lactoferrin has been developed. The analyte concentration dependent fluorescence emission, caused by the sensitization of pre-deposited terbium (Tb(3+)) upon complexation with lactoferrin on the paper device, is captured using a digital camera. The dynamic response(More)
Long-term stable ratiometric fluorescent optical pH sensors (optodes) based on double sol-gel silica layers are prepared with the first layer embedding two types of quantum dots (QDs) and the second layer embedding light-absorbing pH indicators. The sensors are fabricated by a simple general sol-gel spin-coating method. The resulting double-layer pH optodes(More)
Mg(2+) plays important roles in numerous cellular functions. Mitochondria take part in intracellular Mg(2+) regulation and the Mg(2+) concentration in mitochondria affects the synthesis of ATP. However, there are few methods to observe Mg(2+) in mitochondria in intact cells. Here, we have developed a novel Mg(2+)-selective fluorescent probe, KMG-301, that(More)
A new nanoparticulate inorganic-organic hybrid-type positive contrast agent (CA), PGP/dextran-K01, was synthesized based on a GdPO4 inorganic core as a relaxation-time-shortening moiety and a dextran-coating, which generates monodispersibility in water, a high relaxation-time-shortening effect by retaining a large number of water molecules in proximity of(More)
This paper reports on an inkjet printing method for the fabrication of lateral flow immunochromatographic devices made from a single piece of filter paper by patterning microfluidic channels and dispensing immunosensing inks, requiring only a single printing apparatus. This "paperfluidic" immunosensing device allows for a less time-consuming and more(More)
An amperometric biosensor has been developed for measurement of Umami, or the taste based on the amount of L-glutamate, in tomato foods. The biosensor is based on an enzyme-mediator system in which L-glutamate oxidase is used for biochemical oxidation of L-glutamate and a tetrafulvalene-tetracyanoquinodimethane (TTF-TCNQ) paste, prepared from the mixture of(More)
We report a novel near-infrared fluorescent calcium probe (KFCA), which has good optical properties such as intense NIR fluorescence emission (670 nm, QY: 0.24), excellent ON/OFF ratio (120-fold), and good wavelength-compatibility with visible-light-emissive fluorophores (Fluo-4, DsRed2), and which is applicable for real-time dual-colour intracellular(More)
A new method based on artificial neural networks (ANN) for the processing of spectrophotometric data is proposed and illustrated on the example of the simultaneous quantification of ternary mixtures of zinc, cadmium, and mercury cations in aqueous solutions. Three types of commercially available metallochromic indicators were used as a simple model setup to(More)