Umesh D. Parashar7
Michael D. Bowen3
Geoffrey A. Weinberg3
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Although recognized as the leading cause of epidemic acute gastroenteritis across all age groups, norovirus has remained poorly characterized with respect to its endemic disease incidence. Use of different methods, including attributable proportion extrapolation, population-based surveillance, and indirect modeling, in several recent studies has(More)
BACKGROUND The Institute of Medicine has identified patient safety as a key goal for health care in the United States. Detecting vaccine adverse events is an important public health activity that contributes to patient safety. Reports about adverse events following immunization (AEFI) from surveillance systems contain free-text components that can be(More)
Large amounts of information are locked up in free text components of clinical reports. Surveillance systems that monitor adverse events following immunizations (AEFI) can utilize these components after concept extraction using natural language processing (NLP). Specifically, our method for the identification and filtering of negated concepts using the(More)
Surveillance for rotavirus-associated diarrhea after implementation of rotavirus vaccination can assess vaccine effectiveness and identify disease-associated genotypes. During active vaccine postlicensure surveillance in the United States, we found a novel rotavirus genotype, G14P[24], in a stool sample from a child who had diarrhea. Unusual rotavirus(More)
  • Mary E. Wikswo, Rishi Desai, Kathryn M. Edwards, Mary Allen Staat, Peter G. Szilagyi, Geoffrey A. Weinberg +6 others
  • 2013
Methods Persons included in the study were enrolled as New Vaccine Surveillance Network study participants (n = 1,897) and had a fecal specimen collected (n = 1,363, 72%) that was tested for norovirus and rotavirus (n = 1,295, 95%) (Technical Appendix Figure 1). Pentavalent rotavirus vaccine (RV5) for routine use in US infants in February 2006 in children(More)
We compared rotavirus detection rates in children with acute gastroenteritis (AGE) and in healthy controls using enzyme immunoassays (EIAs) and semiquantitative real-time reverse transcription PCR (qRT-PCR). We calculated rotavirus vaccine effectiveness using different laboratory-based case definitions to determine which best identified the proportion of(More)
inter vomiting disease " was the clinical moniker for viral acute gastroenteritis (AGE), including illnesses caused by norovirus and rotavirus, nearly 100 years ago (1). This nonspecific diagnosis represented a frequently observed illness, with the symptoms of vomiting and diarrhea that occurred particularly in the colder months. One hundred years later,(More)
BACKGROUND In 2010, researchers using novel laboratory techniques found that US-licensed rotavirus vaccines contain DNA or DNA fragments from Porcine circovirus (PCV), a virus common among pigs but not believed to cause illness in humans. We sought to understand pediatricians' and mothers' perspectives on this finding. METHODS We conducted three(More)
To determine how long antibodies against Middle East respiratory syndrome coronavirus persist, we measured long-term antibody responses among persons serologically positive or indeterminate after a 2012 outbreak in Jordan. Antibodies, including neutralizing antibodies, were detectable in 6 (86%) of 7 persons for at least 34 months after the outbreak.
  • Sunando Roy, Kunchala Rungsrisuriyachai, Mathew D. Esona, Julie A. Boom, Leila C. Sahni, Marcia A. Rench +5 others
  • 2015
To the Editor: Group A rotaviruses (RVAs) are a leading cause of acute gastroenteritis-associated deaths among children <5 years of age in developing countries (1). The genome of RVA consists of 11 double-stranded RNA segments that code for 11 or 12 viral proteins (VP1– VP4, VP6, VP7, nonstructural protein 1 [NSP1]–NSP5/6) (2). In 2008, the Rotavirus(More)