Daniel C Nelson

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Daniel C Nelson, Mathias Schmelcher, +4 authors David M. Donovan
Advances in virus research
2012

Peptidoglycan (PG) is the major structural component of the bacterial cell wall. Bacteria have autolytic PG hydrolases that allow the cell to grow and divide. A well-studied group of PG hydrolase… (More)

Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium.

Pauline Yoong, Raymond Schuch, Daniel C Nelson, Vincent A. Fischetti
Journal of bacteriology
2004

Enterococcus faecalis and Enterococcus faecium infections are increasingly difficult to treat due to high levels of resistance to antibiotics. PlyV12, a bacteriophage lytic enzyme, was isolated and… (More)

X-ray crystal structure of the streptococcal specific phage lysin PlyC.

Sheena McGowan, Ashley M. Buckle, +9 authors Daniel C Nelson
Proceedings of the National Academy of Sciences…
2012

Bacteriophages deploy lysins that degrade the bacterial cell wall and facilitate virus egress from the host. When applied exogenously, these enzymes destroy susceptible microbes and, accordingly,… (More)

Purification and Characterization of Biofilm-Associated EPS Exopolysaccharides from ESKAPE Organisms and Other Pathogens

Patrick M. Bales, Emilija Miljkovic Renke, Sarah L. May, Yang Shen, Daniel C Nelson
PloS one
2013

In bacterial biofilms, high molecular weight, secreted exopolysaccharides can serve as a scaffold to which additional carbohydrates, proteins, lipids, and nucleic acids adhere, forming the matrix of… (More)

Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection.

Mathias Schmelcher, Yang Shen, +10 authors David M. Donovan
The Journal of antimicrobial chemotherapy
2015

OBJECTIVES In the light of increasing drug resistance in Staphylococcus aureus, bacteriophage endolysins [peptidoglycan hydrolases (PGHs)] have been suggested as promising antimicrobial agents. The… (More)

Reinventing phage therapy: are the parts greater than the sum?

Vincent A. Fischetti, Daniel C Nelson, Raymond Schuch
Nature Biotechnology
2006

Although whole phage continue to generate interest as an alternative to antibiotics, focus is shifting to the use of purified phage components as antibacterial agents.

PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis.

Pauline Yoong, Raymond Schuch, Daniel C Nelson, Vincent A. Fischetti
Journal of bacteriology
2006

We have cloned a lytic enzyme, PlyPH, with a specific lytic effect on Bacillus anthracis strains. PlyPH remains active between pH 4 and 10.5, and a single dose rescued a significant percentage of… (More)

Complete Genome Sequence of Bacillus cereus Sensu Lato Bacteriophage Bcp1

Raymond Schuch, Adam J. Pelzek, Monica M. Fazzini, Daniel C Nelson, Vincent A. Fischetti
Genome announcements
2014

Bacillus cereus sensu lato organisms are an ecologically diverse group that includes etiologic agents of food poisoning, periodontal disease, and anthrax. The recently identified Bcp1 bacteriophage… (More)

Cysteine proteinase SpeB from Streptococcus pyogenes - a potent modifier of immunologically important host and bacterial proteins.

Daniel C Nelson, Julia Garbe, Mattias Collin
Biological chemistry
2011

Group A streptococcus (Streptococcus pyogenes) is an exclusively human pathogen that causes a wide spectrum of diseases ranging from pharyngitis, to impetigo, to toxic shock, to necrotizing… (More)

Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus

Stephen C. Becker, Dwayne R. Roach, +20 authors David M. Donovan
Scientific reports
2016

Multi-drug resistant bacteria are a persistent problem in modern health care, food safety and animal health. There is a need for new antimicrobials to replace over used conventional antibiotics. Here… (More)

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