Daniel C. Morton

Learn More
BACKGROUND Brain imaging and behavioral studies suggest an inverse relationship between dopamine (DA) D2/D3 receptors and vulnerability to cocaine abuse, although most research has used males. For example, male monkeys that become dominant in a social group have significant elevations in D2/D3 receptor availability and are less vulnerable to cocaine(More)
Human cytochrome P450 aromatase catalyzes with high specificity the synthesis of estrogens from androgens. Aromatase inhibitors (AIs) such as exemestane, 6-methylideneandrosta-1,4-diene-3,17-dione, are preeminent drugs for the treatment of estrogen-dependent breast cancer. The crystal structure of human placental aromatase has shown an androgen-specific(More)
The objective of this work is to provide analytical guidelines and financial justification for the design of shared-vehicle mobility-on-demand systems. Specifically, we consider the fundamental issue of determining the appropriate number of vehicles to field in the fleet, and estimate the financial benefits of several models of car sharing. As a case study,(More)
This tutorial review presents a description of the controlling elements of intermolecular C-H functionalization by means of C-H insertion by donor/acceptor rhodium carbenes. These rhodium carbenes, readily derived from the combination of diazo compounds with dirhodium(ii) catalysts, are sufficiently reactive to undergo a wide range of C-H insertions. They(More)
This paper introduces a generalization of Fibonacci and Pell polynomials in order to obtain optimal second-order bounds for general linear recurrences with negative coefficients. An important aspect of the derived bounds is that they are applicable and easily computable. The results imply bounds on all entries in inverses of triangular matrices as well as(More)
The preparation and reactivity of steroidal vinyldiazo compounds is reported, providing a convenient, substituent tolerant, chemo- and stereoselective entry into 4- and 6-substituted androgen analogues from a common precursor. Under dirhodium catalysis, O-H insertion occurs at the carbenoid site, leading to 4-substituted steroids, but under silver(More)
The purpose of diversity-oriented synthesis is to drive the discovery of small molecules with previously unknown biological functions. Natural products necessarily populate biologically relevant chemical space, since they bind both their biosynthetic enzymes and their target macromolecules. Natural product families are, therefore, libraries of(More)
This short note provides an improvement on a recent result of Vecchio on a norm bound for the inverse of a lower triangular Toeplitz matrix with nonnegative entries. A sharper asymptotic bound is obtained in addition to a version for matrices of finite order. The results are shown to be nearly best possible under the given constraints. 1. Introduction. This(More)