Daniel C.H. Kwan

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Hyperpolarization-activated cyclic nucleotide-sensitive nonselective cation (HCN) channels are activated by membrane hyperpolarization, in contrast to the vast majority of other voltage-gated channels that are activated by depolarization. The structural basis for this unique characteristic of HCN channels is unknown. Interactions between the S4-S5 linker(More)
The twin-arginine translocase (Tat) is a system specific to the transport of fully folded proteins. In contrast to most prokaryotes, the Tat pathway is the main route for export in halophilic archaea (haloarchaea). The haloarchaeal Tat system also seems to differ in a number of other aspects from the nonhalophilic counterparts, such as the constituents of(More)
Twin-arginine translocase (Tat) is involved in the translocation of fully folded proteins in a process that is driven by the proton motive force. In most prokaryotes, the Tat system transports only a small proportion of secretory proteins, and Tat substrates are often cofactor-containing proteins that require folding before translocation. A notable(More)
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