Daniel C Angst

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The persistence of antibiotic resistance depends on the fitness effects of resistance elements in the absence of antibiotics. Recent work shows that the fitness effect of a given resistance mutation is influenced by other resistance mutations on the same genome. However, resistant bacteria acquire additional beneficial mutations during evolution in the(More)
Antibiotic resistance can impair bacterial growth or competitive ability in the absence of antibiotics, frequently referred to as a 'cost' of resistance. Theory and experiments emphasize the importance of such effects for the distribution of resistance in pathogenic populations. However, recent work shows that costs of resistance are highly variable(More)
BACKGROUND Despite being used by more than 18 million people our understanding of the extent of effects of antiretrovirals on the human body and other organisms remains incomplete. In addition, the direct effect of antiretrovirals on the gut microbiota of HIV infected individuals has been largely overlooked in microbiome studies concerned with HIV infected(More)
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