Learn More
The purpose of the present study was to investigate whether an energy failure level applies to the skull fracture mechanics in unembalmed post-mortem human heads under dynamic frontal loading conditions. A double-pendulum model was used to conduct frontal impact tests on specimens from 18 unembalmed post-mortem human subjects. The specimens were isolated at(More)
In current research with laboratory animals, observing their dynamic behavior or locomotion is a labor-intensive task. Automatic continuous monitoring can provide quantitative data on each animal's condition and coordination ability. The objective of the present work is to develop an automated mouse observation system integrated with a conventional(More)
In this article, an automated and accurate mouse observation method, based on a conventional test for motor function evaluation, is outlined. The proposed measurement technique was integrated in a regular open-field test, where the trajectory and locomotion of a free-moving mouse were measured simultaneously. The system setup consisted of a transparent cage(More)
Cough or cough epochs may be an important and persistent symptom in many respiratory diseases requiring both a continuous and objective observation. The research presented in this paper is aimed at assessing a blind data-based classification between 'spontaneous' and 'voluntary' human cough on individual sound samples. Cough sounds were registered in the(More)
For hatcheries, not only is it important to have a high level of hatchability, but the quality of the chicks provided also has to be good, because broiler farmers are looking for chicks with a high growth potential, resulting in a greater slaughter yield at the end of the rearing period. However, chick quality has proven to be a difficult and subjective(More)
BACKGROUND Spirometric parameters are the mainstay for diagnosis of COPD, but cannot distinguish airway obstruction from emphysema. We aimed to develop a computer model that quantifies airway collapse on forced expiratory flow-volume loops. We then explored and validated the relationship of airway collapse with computed tomography (CT) diagnosed emphysema(More)
This study investigates how integrated bed measurements can be used to assess motor patterns (movements and postures) during sleep. An algorithm has been developed that detects movements based on the time derivate of mattress surface indentation. After each movement, the algorithm recognizes the adopted sleep posture based on an image feature vector and an(More)
Recent advances have started to uncover the underlying mechanisms of metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD). However, it is not completely clear how these mechanisms are linked, and it is believed that several crucial mechanisms remain to be revealed. In this study, we investigated whether system identification (SI)(More)
Arylsulfatase A (ASA)-deficient mice represent an animal model for the lysosomal storage disorder metachromatic leukodystrophy (MLD). Although the model has been applied in pathophysiological and therapeutic studies, the behavioural phenotype of ASA(-/-) mice is only partially characterized, and the most decisive outcome measures for therapy evaluation only(More)