Daniel Beltrán-Valero de Bernabé

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N euronal migration is a key process in the development of the cerebral cortex. During neocortex lamination new sets of neurones proliferate at the subventricular zone and migrate alongside specialised radial glial fibres to occupy their final destinations in an ''inside-out'' fashion. 1 More than 25 neuronal migration disorders resulting in death or(More)
My keen interest in the molecular basis of human disease has driven my scientific career—as highlighted by my work to identify mutated genes involved in alkaptonuria, epilepsy of Lafora, Walker-Warburg Syndrome, and epithelial-derived cancer. These scientific discoveries helped to open up new areas of research for these diseases. During my graduate studies(More)
BACKGROUND Polymorphonuclear neutrophils (PMN) constitute an essential cellular component of innate host defense against microbial invasion and exhibit a wide array of responses both to particulate and soluble stimuli. As the cells recruited earliest during acute inflammation, PMN respond rapidly and release a variety of potent cytotoxic agents within(More)
Both LARGE1 (formerly LARGE) and its paralog LARGE2 are bifunctional glycosyltransferases with xylosy- and glucuronyltransferase activities, and are capable of synthesizing polymers composed of a repeating disaccharide [-3Xylα1,3GlcAβ1-]. Post-translational modification of the O-mannosyl glycan of α-dystroglycan (α-DG) with the polysaccharide is essential(More)
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