Daniel B. Gould

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OBJECTIVE To better delineate the clinical spectrum and the natural history of COL4A1 mutations, a newly defined genetic cause of small vessel disease including the brain and retina. METHODS Clinical and brain MRI follow-up study of a family with COL4A1 mutation. RESULTS During a 7-year period, two affected members died from intracranial hemorrhage.(More)
BACKGROUND Subintimal dissection with acute occlusion of the internal carotid artery resulting in acute cerebral infarction has not been reported as an iatrogenic complication of general anesthesia. CASE DESCRIPTIONS An anesthetist stretched the neck of a 44-year-old man by anchoring an anesthesia mask posterior to the angle of the jaw with overlying(More)
Differently designed right atrial venous air embolism retrieval catheters were tested in vitro in clinical simulations to determine if increasing numbers of aspirating orifices enhance the recovery of air bubbles by aspirating through these catheters. Air bubbles of 1.5 to 2.0 mm diameter were directly observed to pass against the aspirating orifices while(More)
Bradycardia and hypotension were the first major signs of toxicity from a 250 mg bupivacaine axillary brachial plexus block experienced by a patient with chronic renal failure, who had an anion gap acidosis and hyperkalaemia. Without these metabolic abnormalities, this patient received four similar blocks: three were without incident and one was complicated(More)
In a patient with chronic hepatosplenic schistosomiasis a segmental sclerosing nephropathy led to terminal renal failure. The demonstration of glomerular capillary deposition of immunoglobulin and complement with electron dense deposits and lucent deformities of the glomerular basement membrane and the presence of antischistosome adult worm antibody in(More)