Daniel A. Ward

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OBJECTIVE To determine the effects of commonly used ophthalmic corticosteroids, suprofen, polysulfated glycosaminoglycan and preservatives on morphologic characteristics and migration of canine corneal epithelium grown in cell culture. ANIMALS STUDIED Corneal epithelial cells harvested from the corneas of euthanized dogs were propagated in cell culture.(More)
OBJECTIVE To evaluate the effect of vaccination against leptospirosis on frequency and days to recurrence of uveitis and progression of disease in horses with equine recurrent uveitis (ERU). ANIMALS Forty-one horses with ERU. PROCEDURE Horses were randomly assigned to experimental (vaccinated) or control groups. Vaccine containing six serovars of(More)
OBJECTIVE To assess the effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase (AChE) levels in normal dogs. ANIMALS Nine adult mixed breed dogs weighing between 18 and 27 kg. PROCEDURES Fifty micro L of 0.25% demecarium bromide were applied to one eye of each dog every 8 h for 6 days. Blood was analyzed for AChE(More)
OBJECTIVE To determine ocular tissue drug concentrations after topical ocular administration of 0.3% ciprofloxacin and 0.5% moxifloxacin in ophthalmologically normal horses. ANIMALS 24 ophthalmologically normal adult horses. PROCEDURES 0.3% ciprofloxacin and 0.5% moxifloxacin solutions (0.1 mL) were applied to the ventral conjunctival fornix of 1 eye in(More)
The migration of uncemented press-fit CLS (Cementless Total Hip Replacement System) acetabular cups was measured retrospectively from standard anteroposterior pelvic radiographs using a digitizer and software specifically developed for this study. A radiographic and clinical review also were undertaken. There were 96 patients in the study group. The mean(More)
CASE DESCRIPTION A 7-month-old 16.6-kg (36.5-lb) sexually intact female Golden Retriever was evaluated because of progressive severe bilateral membranous conjunctivitis, oral lesions, nasal discharge, and cough. CLINICAL FINDINGS Histologic examination of conjunctival biopsy specimens revealed findings consistent with ligneous conjunctivitis. Circulating(More)
PURPOSE Previously, we mapped the disease locus in the beagle model of autosomal recessive primary open angle glaucoma (POAG) to a 4-Mb interval on chromosome 20, and identified a Gly661Arg variant in ADAMTS10 as the candidate disease-causing variant. The purpose of this study was to test the hypothesis that the Gly661Arg variant of ADAMTS10 causes glaucoma(More)
OBJECTIVE To compare induction and recovery characteristics and cardiopulmonary effects of isoflurane and sevoflurane in bald eagles. Animals-17 healthy adult bald eagles. PROCEDURES Anesthesia was induced with isoflurane or sevoflurane delivered in oxygen via a facemask in a crossover design with 4 weeks between treatments. Eagles were intubated, allowed(More)
Two groups, each consisting of six male rats, breathed 21% O2-4% CO2 or 10% O2-4% CO2, respectively, before and after carotid sinus nerve (CSN) transection. Polygraphic recording techniques served to monitor sleep and wakefulness. The effects of these gas mixtures on the sleep-waking pattern (SWP) were studied. The SWPs of the intact and CSN-transected rats(More)
OBJECTIVE To determine the effects of topically applied 2% delta-9-tetrahydrocannabinol (THC) ophthalmic solution on aqueous humor flow rate (AHFR) and intraocular pressure (IOP) in clinically normal dogs. ANIMALS 21 clinically normal dogs. PROCEDURES A randomized longitudinal crossover design was used. Following acquisition of baseline IOP (morning and(More)