Danica Nastić-Mirić

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BACKGROUND The pathophysiology of renal ischaemia, resulting in tubular cell injury and leading to acute renal failure (ARF), remains unclear. An ever-increasing number of investigations focus on a possible role of nitric oxide (NO) in regulating circulation during ARF. In this context, we investigated the influence of chronic stimulation or inhibition of(More)
PURPOSE To assess whether the expression of estrogen-induced protease, cathepsin D, might facilitate biological subgrouping of patients with breast carcinomas, and accordingly, its potential applicability in clinical oncology. PATIENTS AND METHODS This study includes 70 patients with histologically confirmed breast carcinoma. Pathological findings were(More)
BACKGROUND The relative roles of endothelin (ET)-1 and angiotensin (ANG) II in post-ischaemic acute renal failure (ARF) have not been fully established so far. With the aim of contributing to this goal, we assessed in this study the effect of ANG II and ET-1 blockade on the course of post-ischaemic-ARF. METHODS Anaesthetized Wistar rats received i.v.(More)
Having previously established the specificity of a newly developed radiolabeled polyclonal anti fibrin antibody (AFA) for tagging fibrin depositions, clinical experiments for validation of this agent for imaging deep vein thromboses (DVT) were carried out in comparison with labeled human serum albumin (HSA) and labeled platelets. Patients with DVT were(More)
A simplified and efficient procedure for 99mTc-HMPAO-labelling of leukocytes is described. For this purpose, the pH and concentration of the 99mTc-HMPAO preparation was modified. Leukocytes were isolated from a 20 mL mixture of patient blood, 5 mL ACD and 0.8 mL methylcellulose after 1 h sedimentation of erythrocytes and centrifugation (at 400 g) of the(More)
The study presents preliminary results and suggests the role of scintigraphy of synthetic vascular prosthesis by 99mTc-HMPAO labelled leukocytes for detection of graft infections. Analysis of the results obtained revealed true positive in 6, true negative in 3 and suspicious findings in 3 patients (in one of them the suspicious was confirmed on(More)
BACKGROUND Inhibition of nitric oxide (NO) synthase by L-arginine analogs is associated with elevation of blood pressure in rats. Because endothelium-dependent vasomotion in different vascular beds is not homogenous, the aim of this study was to characterize and compare regional hemodynamic responses in carotid, femoral, and renal vascular beds after(More)
Helicobacter pylori infection is supposed to be one of the major causes of digestive and other diseases. Among a lot of invasive and non-invasive methods for its detection, none is ideal. The aim is an assessment of the Helicobacter pylori infection in the stomach using breath test and comparison to other diagnostic methods, as well as following up the(More)
The authors present a patient with delayed-type allergy against insulin preparations of different species including highly purified monocomponent insulin and human semisynthetic insulin. Positive results for cutaneous delayed-type hypersensitivity and for lymphocyte blastogenesis suggested a type IV immunopathogenic reaction. Intradermal tests performed(More)