Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine
- Yifan Zhang, A. Kecskés, Camila V. Esguerra
- Biology, PsychologyPLoS ONE
- 12 May 2015
This is the first study demonstrating effective seizure inhibition of fenfluramine in an animal model of Dravet syndrome, and these results provide a basis for identifying novel analogs with improved activity and significantly milder or no side effects.
Use of Zebrafish Larvae as a Multi-Endpoint Platform to Characterize the Toxicity Profile of Silica Nanoparticles
- D. Pham, Bert De Roo, P. D. de Witte
- BiologyScientific Reports
- 22 November 2016
The results suggest that silica NPs do not cause any developmental, cardio- or hepatotoxicity, but they pose a potential risk for the neurobehavioral system.
Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A.
- Daniëlle Copmans, M. Rateb, P. D. de Witte
- Biology, ChemistryACS Chemical Neuroscience
- 19 April 2018
This study provides the first evidence of antiseizure activity of pseurotins and azaspirofurans, and demonstrates the value of the zebrafish model in (marine) natural product drug discovery in general, and for ASD discovery in particular.
Methylated flavonoids as anti-seizure agents: Naringenin 4′,7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models
- Daniëlle Copmans, A. Orellana-Paucar, P. Witte
- BiologyNeurochemistry International
- 31 January 2018
Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040
- E. Sonnenschein, Marc Stierhof, J. Tabudravu
- Biology
- 4 May 2017
A KNIME-Based Analysis of the Zebrafish Photomotor Response Clusters the Phenotypes of 14 Classes of Neuroactive Molecules
- Daniëlle Copmans, T. Meinl, P. D. de Witte
- BiologyJournal of biomolecular screening
- 1 June 2016
An automated analysis workflow using the KNIME Analytics Platform is developed that allows to simultaneously calculate a behavioral fingerprint for all analyzed compounds and to further process the data, and different phenotypical clusters were observed that suggest the utility of PMR for mechanism prediction for adrenergics, dopaminergic, serotonergics and metabotropic glutamatergics, opioids, and ion channel ligands.
Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy
- B. Hunyadi, A. Siekierska, Jo Sourbron, Daniëlle Copmans, P. Witte
- BiologyJournal of Neuroscience Methods
- 1 August 2017
Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Magnolia officinalis Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in…
- Jing Li, Daniëlle Copmans, M. Partoens, B. Hunyadi, W. Luyten, P. D. de Witte
- BiologyACS Chemical Neuroscience
- 21 February 2020
Allyl biphenol was identified as a chemical scaffold for the future development of compounds with potential activity against therapy-resistant epilepsies, and magnolol and honokiol displayed an effective behavioral and electrophysiological antiseizure activity in both the PTZ and the EKP models.
mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis
- C. Scheldeman, J. D. Mills, P. Witte
- BiologyNeurobiology of Disease
- 1 December 2017
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