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Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine
TLDR
This is the first study demonstrating effective seizure inhibition of fenfluramine in an animal model of Dravet syndrome, and these results provide a basis for identifying novel analogs with improved activity and significantly milder or no side effects.
Use of Zebrafish Larvae as a Multi-Endpoint Platform to Characterize the Toxicity Profile of Silica Nanoparticles
TLDR
The results suggest that silica NPs do not cause any developmental, cardio- or hepatotoxicity, but they pose a potential risk for the neurobehavioral system.
Methylated flavonoids as anti-seizure agents: Naringenin 4′,7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models
TLDR
NRG‐DM is proposed as a lead compound that is worth further investigation for the treatment of generalized seizures and drug‐resistant focal seizures, and the potential of methylated flavonoids is highlighted in the search for new and improved ASDs.
Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040
Acknowledgements This work was supported by the EU seventh Framework Programme Project ‘PharmaSea’ (Grant agreement no. 312184). BFM acknowledges funding from the Portuguese Foundation for Science
Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A.
TLDR
This study provides the first evidence of antiseizure activity of pseurotins and azaspirofurans, and demonstrates the value of the zebrafish model in (marine) natural product drug discovery in general, and for ASD discovery in particular.
A KNIME-Based Analysis of the Zebrafish Photomotor Response Clusters the Phenotypes of 14 Classes of Neuroactive Molecules
TLDR
An automated analysis workflow using the KNIME Analytics Platform is developed that allows to simultaneously calculate a behavioral fingerprint for all analyzed compounds and to further process the data, and different phenotypical clusters were observed that suggest the utility of PMR for mechanism prediction for adrenergics, dopaminergic, serotonergics and metabotropic glutamatergics, opioids, and ion channel ligands.
mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis
TLDR
The phenotypic, transcriptomic and pharmacological analysis identified the tsc2-/- zebrafish as a preclinical model that mirrors well aspects of the human condition and delineated relevant TSC-related biological pathways.
Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy
TLDR
An automated algorithm to detect epileptic discharges in single-channel local field potential recordings in zebrafish LPF is presented, which can replace visual analysis and facilitate true high-throughput studies.
Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Magnolia officinalis Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in
TLDR
Allyl biphenol was identified as a chemical scaffold for the future development of compounds with potential activity against therapy-resistant epilepsies, and magnolol and honokiol displayed an effective behavioral and electrophysiological antiseizure activity in both the PTZ and the EKP models.
Zebrafish Models of Epilepsy and Epileptic Seizures
TLDR
This chapter describes zebrafish models of epilepsy and epileptic seizures generated by various pharmacological and genetic manipulations, with a focus on current methods to monitor and characterize seizure-related activities.
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