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BACKGROUND Damaged articular cartilage has limited capacity for self-repair. Autologous chondrocyte implantation using a characterized cell therapy product results in significantly better early structural repair as compared with microfracture in patients with symptomatic joint surface defects of the femoral condyles of the knee. PURPOSE To evaluate(More)
BACKGROUND As the natural healing capacity of damaged articular cartilage is poor, joint surface injuries are a prime target for regenerative medicine. Characterized chondrocyte implantation uses an autologous cartilage cell therapy product that has been optimized for its biological potency to form stable cartilage tissue in vivo. PURPOSE To determine(More)
BACKGROUND Characterized chondrocyte implantation (CCI) results in significantly better early structural tissue regeneration than microfracture (MF), and CCI has a midterm clinical benefit over microfracture. PURPOSE This study was undertaken to evaluate the 5-year clinical outcome of CCI in a randomized comparison with MF for the treatment of symptomatic(More)
OBJECTIVE For young patients with cartilage defects, the emergence of clinically applicable cell therapy for biological joint reconstruction is an appealing prospect. Acceptation of this method as a means of standard care requires proof of being reproducible, having long-lasting mechanical integrity, and having a good clinical outcome. This study evaluates(More)
The objective was to evaluate the functional performance over a 2-year period following autologous chondrocyte implantation (ACI) in an open knee procedure compared to microfracture. Objective functional outcome was studied as secondary analysis in a subgroup of patients, in a randomized clinical trial, with concealed allocation and independent evaluators.(More)
BACKGROUND Several treatment options are available to repair articular cartilage lesions of the knee; however, evidence-based parameters for treatment selection are lacking. PURPOSE To identify parameters for valid treatment selection in the repair of articular cartilage lesions of the knee. STUDY DESIGN Systematic review. METHODS A systematic search(More)
BACKGROUND Cartilage therapy for focal articular lesions has been implemented for more than a decade, and it is becoming increasingly available. What is still lacking, however, is analysis of patient characteristics to help improve outcome or select patients for specific treatment. PURPOSE To analyze the prognostic value of patient age and defect size,(More)
PURPOSE The goal of this study was to evaluate strength and functional capacity before and after anterior cruciate ligament (ACL) reconstruction to determine the influences of preoperative strength deficit, graft type, and gender, as well as their clinical relevance in predicting postsurgical recovery and determining the postoperative rehabilitation(More)
Regenerative medicine approaches based on decellularized extracellular matrix (ECM) scaffolds and tissues are rapidly expanding. The rationale for using ECM as a natural biomaterial is the presence of bioactive molecules that drive tissue homeostasis and regeneration. Moreover, appropriately prepared ECM is biodegradable and does not elicit adverse immune(More)
BACKGROUND Growing awareness of the biomechanical contribution of the medial patellofemoral ligament has led to an upsurge in the publication of techniques and trials dealing with reconstructive techniques, warranting a review that includes the most recent evidence. STUDY DESIGN Systematic review. METHODS The authors undertook a systematic electronic(More)