Danièle Demarquay

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We have previously demonstrated that the beta 2-adrenoceptor agonist, salbutamol, potentiates the effect of interleukin-4 (IL-4) on immunoglobulin E (IgE) production by human peripheral blood mononuclear cells (PBMC). This study was undertaken to further define the activities of these drugs and the role of cyclic-adenosine monophosphate (cAMP) in the(More)
BN80927 belongs to a novel family of camptothecin analogs, the homo-camptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered ␤-hydroxylac-tone ring. Preclinical data reported here show that BN80927 retains Topo I poisoning activity in cell-free assay (DNA relaxation) as well as in living(More)
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