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Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines.
TLDR
These studies provide support for the use of resveratrol in chemoprevention and cancer therapy trials and suggest Cyclin D1, cyclin B1, beta-catenin, and apoptotic index could be useful biomarkers to evaluate treatment efficacy. Expand
Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation.
TLDR
The garlic-derived compound SAMC exerts antiproliferative effects by binding directly to tubulin and disrupting the MT assembly, thus arresting cells in mitosis and triggering JNK1 and caspase-3 signaling pathways that lead to apoptosis. Expand
Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cells
TLDR
Structural-function analysis suggests that both the allyl and the disulfide moieties are important features for the antiproliferative effects of SAMC and DADS and may be useful in the identification, synthesis, and development of organosulfur compounds that have anticancer activity. Expand
Mechanisms of Neuroprotection from Hypoxia-Ischemia (HI) Brain Injury by Up-regulation of Cytoglobin (CYGB) in a Neonatal Rat Model*
TLDR
The reduction of neonatal HI injury by CYGB may be due in part to antioxidant and antiapoptotic mechanisms and by promoting angiogenesis and the first in vivo study focusing on the neuroprotective role of CYGB. Expand
Growth Inhibitory Activity of Extracts and Purified Components of Black Cohosh on Human Breast Cancer Cells
The purpose of this study was to determine whether black cohosh contains constituents that inhibit the growth of human breast cancer cells, and therefore might eventually be useful in the preventionExpand
Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.
TLDR
Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells. Expand
Synergistic Effects of Acyclic Retinoid and OSI-461 on Growth Inhibition and Gene Expression in Human Hepatoma Cells
TLDR
The results suggest that the combination of acyclic retinoid plus OSI-461 might be an effective regimen for the chemoprevention and chemotherapy of human hepatoma and possibly other malignancies. Expand
The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization
TLDR
The results suggest that the dual effects of OSI-461, OSIP486823, and OSIP487703 on impairment of microtubule functions and protein kinase G activation may explain the potent antiproliferative and apoptotic effects of these compounds in cancer cells. Expand
CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells.
TLDR
In glioma cells, the effects of CP248 on MTs were independent of the previously reported effects of this compound on activation of protein kinase G, and CP248 is a novel MT-active agent that may be useful in the treatment of glioblastoma, and possibly other types of cancer. Expand
Exisulind and CP248 induce growth inhibition and apoptosis in human esophageal adenocarcinoma and squamous carcinoma cells.
TLDR
Support is provided for the use of exisulind in BE chemoprevention trials, and of ex isulind or CP248 in the therapy of patients with esophageal carcinoma, suggesting that JNK1 activation plays a role in the induction of apoptosis by these compounds. Expand
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