Danhong Yan

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The nicotinic acetylcholine receptor (AChR) and the serotonin type 3 receptor (5HT3R) are members of the ligand-gated ion channel gene family. Both receptors are inhibited by nanomolar concentrations of d-tubocurarine (curare) in a competitive fashion. Chemical labeling studies on the AChR have identified tryptophan residues on the gamma (gammaTrp-55) and(More)
D-Tubocurarine is a potent competitive antagonist of two members of the ligand-gated ion channel family, the muscle-type nicotinic acetylcholine receptor (AChR) and serotonin type-3 receptor (5HT3R). We have used a series of analogs of D-tubocurarine to determine the effects of methylation, stereoisomerization and halogenation on the interaction of(More)
Peptides are emerging as pharmaceutical agents in cancer therapy. The peptide, TLSGAFELSRDK (TLS) is a targeting ligand that can specifically triggers cellular uptake by binding to SKOV3 cells. Cell surface proteins and the C-terminal basic residues of the TLS are required for effective cell penetration, and the uptake process is energy-dependent. It(More)
The cyclic peptide Cys-Asn-Gly-Arg-Cys (CNGRC) has previously been demonstrated as a tumor vasculature-homing peptide, which can specifically bind to CD13/aminopeptidase N in vivo. However, the effect of the peptide (CNGRC) binding to tumor cells in vitro has not yet been reported. In this study, CNGRC and an irrelevant linear control peptide (SVSVG) were(More)
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