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Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment
TLDR
A novel model recapitulating 3D tumor-stroma interactions for studies of real-time cell invasion and morphological changes within a single platform is shown. Expand
Electrospun biodegradable elastic polyurethane scaffolds with dipyridamole release for small diameter vascular grafts.
TLDR
Improved non-thrombogenicity of the DPA-loaded BPU scaffolds was evidenced with extended human blood clotting time, lower TAT complex concentration, lower hemolysis and reduced human platelet deposition, and the attractive mechanical properties and biofunctions indicate its potential as an acellular biodegradable SDVG for vascular replacement. Expand
Improved properties of bone and cartilage tissue from 3D inkjet-bioprinted human mesenchymal stem cells by simultaneous deposition and photocrosslinking in PEG-GelMA
TLDR
Inkjet bioprinted-hMSCs in simultaneously photocrosslinked PEG-GelMA hydrogel scaffolds demonstrated an improvement of mechanical properties and osteogenic and chondrogenic differentiation, suggesting its promising potential for usage in bone and cartilage tissue engineering. Expand
A three-dimensional (3D) organotypic microfluidic model for glioma stem cells - Vascular interactions.
TLDR
A 3D organotypic microfluidic platform, integrated with hydrogel-based biomaterials, is developed to mimic the GSC vascular niche and study the influence of endothelial cells (ECs) on patient-derived GSC behavior and identify signaling cues that mediate their invasion and phenotype. Expand
PNIPAAm-based biohybrid injectable hydrogel for cardiac tissue engineering.
TLDR
A new class of biohybrid temperature-responsive poly(N-isopropylacrylamide) PNIPAAm-Gelatin-based injectable hydrogel with suitable bioactivity and mechanical properties for cardiac tissue engineering is introduced. Expand
Microfluidic Tumor–Vascular Model to Study Breast Cancer Cell Invasion and Intravasation
TLDR
A novel 3D microfluidic platform comprised of concentric three-layer cell-laden hydrogels for simultaneous investigation of breast cancer cell invasion and intravasation as well as vasculature maturation influenced by tumor-vascular crosstalk is developed and it was demonstrated that the presence of spontaneously formed vasculatures enhance MDA-MB-231 invasion into the 3D stroma. Expand
A three dimensional micropatterned tumor model for breast cancer cell migration studies.
TLDR
The results indicate that gelatin methacrylate hydrogel, integrated with the two-step photolithography technique, has great promise in the development of 3D tumor models with well-defined architecture and tunable stiffness. Expand
Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis.
TLDR
The biological significance of each step of the metastatic cascade is discussed and a broad overview on recent progress to recapitulate these stages using advanced biomaterials and microengineered technologies is provided. Expand
Electrically conductive hydrogel-based micro-topographies for the development of organized cardiac tissues
The dense uniaxially aligned cardiac cytoarchitecture of the myocardium along with electrical and mechanical coupling between the cardiac cells are key factors in the synchronous contractility of theExpand
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