Danelle Badenhorst

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BACKGROUND Inflammatory immune activation commonly occurs in heart failure and may perpetuate this syndrome. We sought to determine whether the immunomodulating agent pentoxifylline enhances left ventricular function in patients with ischemic cardiomyopathy. We also investigated the effect of therapy on levels of brain natriuretic peptide (NT-pro BNP),(More)
It is uncertain whether chronic beta-adrenoreceptor (beta-AR)-activation in hypertension could initiate the progression from compensated left ventricular (LV) hypertrophy to pump dysfunction. It is also uncertain if this effect is through adverse LV remodeling (chamber dilatation with wall thinning and pump dysfunction) or intrinsic myocardial contractile(More)
β 1-and α 2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry Summary Background: Although the β 1-adrenoreceptor (AR) Gly389Arg and α 2C-AR del322-325 gene variants are associated with the response to β-AR-blocker therapy, whether this effect is associated with the risk for heart failure, or(More)
The G-308A polymorphism of the tumour necrosis factor-alpha (TNF-alpha) gene, a variant that influences TNF-alpha transcription, may contribute to non-ischaemic dilated cardiomyopathy. To evaluate whether TNF-alpha genotyping may assist in identifying a subset of patients who could potentially benefit from immunomodulatory therapy, we assessed the(More)
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