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Recent evidence demonstrates a correlative relationship between metabolic disorders and cancer prevalence. In addition, cholesterol lowering statins and the antidiabetes medication metformin both act as chemopreventive agents in prostate and other cancers. The natural compound resveratrol has similar properties: increasing insulin sensitivity, suppressing(More)
Epidermal Growth Factor Receptor (EGFR) is involved in stimulating the growth of many human tumors, but the success of therapeutic agents has been limited in part by interference from the EGFR on normal tissues. Previously, we reported an antibody (mab806) against a truncated form of EGFR found commonly in gliomas. Remarkably, it also recognizes full-length(More)
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Early enthusiasm over angiogenic therapy, a method to induce vascular regeneration to treat ischemic tissue with growth factors, has been tempered by a series of unsuccessful clinical trials with limited late efficacy and a wide range of mixed results. This thesis was designed to examine critically whether the lack of late efficacy of local delivery of(More)
The author hereby grants to MIT permission to reproduce and to distribute publicly paper and electronic copies of this thesis document in whole or in part in any medium now known or hereafter created. Abstract Angiogenesis is crucial during many physiological processes, and is influenced by various biochemical and biomechanical factors. Models have proven(More)
Biographical Note and Acknowledgement The author attended Leland Stanford Junior University from 2001 to 2005 and received a Bachelor's of Science in Chemistry with a minor in Biology, and was awarded Distinction for academic performance, Honors for advanced coursework and research, a Firestone Medal for outstanding thesis in the natural sciences and the(More)
Monoclonal antibodies have emerged as an important class of cancer therapeutics due to their ability to specifically bind tumor-expressed antigens. Unfortunately, attempts to treat solid tumors with these drugs are often limited by an inability of the antibodies to fully penetrate the tumor tissue, leaving large regions of untargeted and viable cells. The(More)