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Recent evidence demonstrates a correlative relationship between metabolic disorders and cancer prevalence. In addition, cholesterol lowering statins and the antidiabetes medication metformin both act as chemopreventive agents in prostate and other cancers. The natural compound resveratrol has similar properties: increasing insulin sensitivity, suppressing(More)
Epidermal Growth Factor Receptor (EGFR) is involved in stimulating the growth of many human tumors, but the success of therapeutic agents has been limited in part by interference from the EGFR on normal tissues. Previously, we reported an antibody (mab806) against a truncated form of EGFR found commonly in gliomas. Remarkably, it also recognizes full-length(More)
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The Department of Biological Engineering (BE) continues to grow in terms of world-class faculty and students, innovative educational programs, and leading-edge research programs that advance its mission of fostering education and research that fuses engineering with molecular life sciences. Our central objective is to define and lead the new biology-based(More)
Malaria remains a major burden to global public health. Antimalarial drugs are a mainstay in efforts to control and eventually eradicate this disease. However, increasing drug resistance threatens to reverse recent gains in malaria control, making the discovery of new antimalarials critical. Antimalarial discovery is especially challenging due to the unique(More)
Biographical Note and Acknowledgement The author attended Leland Stanford Junior University from 2001 to 2005 and received a Bachelor's of Science in Chemistry with a minor in Biology, and was awarded Distinction for academic performance, Honors for advanced coursework and research, a Firestone Medal for outstanding thesis in the natural sciences and the(More)
The author hereby grants to MIT permission to reproduce and to distribute publicly paper and electronic copies of this thesis document in whole or in part in any medium now known or hereafter created. Abstract Angiogenesis is crucial during many physiological processes, and is influenced by various biochemical and biomechanical factors. Models have proven(More)