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BACKGROUND Globally, China is the second place with high burden of tuberculosis (TB). To explore the characteristics of the pathogens of Mycobacterium tuberculosis (MTB) circulating in this area is helpful for understanding and controlling the spread of the strains. Recent developments in molecular biology have allowed prompt identification and tracking(More)
BACKGROUND Pulmonary tuberculosis (TB) is a highly lethal infectious disease and early diagnosis of TB is critical for the control of disease progression. The objective of this study was to profile a panel of serum microRNAs (miRNAs) as potential biomarkers for the early diagnosis of pulmonary TB infection. METHODS Using TaqMan Low-Density Array (TLDA)(More)
BACKGROUND Drug resistance has been a cause of concern for tuberculosis (TB) control in both developed and developing countries. Careful monitoring of the patterns and trends of drug resistance should remain a priority. METHODS Strains were collected from 1824 diagnosed sputum smear positive pulmonary TB patients in Jiangsu province of China and then(More)
Embryonic stem cells (ESCs) enable rapid proliferation that also causes DNA damage. To maintain genomic stabilization during rapid proliferation, ESCs must have an efficient system to repress genotoxic stress. Here, we show that withdrawal of leukemia inhibitory factor (LIF), which maintains the self-renewal capability of mouse ESCs (mESCs), significantly(More)
A recent study indicated that apamin-sensitive current (I KAS, mediated by apamin-sensitive small conductance calcium-activated potassium channels subunits) density significantly increased in heart failure and led to recurrent spontaneous ventricular fibrillation. While the underlying molecular correlation with SK channels is still undetermined, we(More)
The study of the free idempotent generated semigroup IG(E) over a biordered set E has recently received a deal of attention. Let G be a group, let n ∈ N with n ≥ 3 and let E be the biordered set of idempotents of the wreath product G ≀ T n. We show, in a transparent way, that for e ∈ E lying in the minimal ideal of G ≀ T n , the maximal subgroup of e in(More)
In this paper we investigate the existence of positive solutions of the following nonlinear semipositone fourth-order two-point boundary-value problem with second derivative: u (4) (t) = f (t, u(t), u (t)), 0 ≤ t ≤ 1, u (1) = u (1) = u (1) = 0, ku(0) = u (0), where −6 < k < 0, f ≥ −M , and M is a positive constant. Our approach relies on the Krasnosel'skii(More)
Change in temperature is often a major environmental factor in triggering waterborne disease outbreaks. Previous research has revealed temporal and spatial patterns of bacterial population in several aquatic ecosystems. To date, very little information is available on aquaculture environment. Here, we assessed environmental temperature effects on bacterial(More)
Streptococcus zooepidemicus is a bacterial pathogen used for production of hyaluronan in industry. Intensive research has significantly contributed to our understanding of S. zooepidemicus biology and pathogenesis. However, the lack of an effective targeted gene inactivation system in S. zooepidemicus has notably prevented the functional genomics analysis(More)