• Publications
  • Influence
Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
  • Yibing Chen, Y. Mi, +10 authors Z. Zou
  • Chemistry, Medicine
  • Journal of experimental & clinical cancer…
  • 13 September 2019
Data suggested that ferroptosis might be a novel anticancer mechanism of DHA in glioma and HSPA5 may serve as a negative regulator of D HA-induced ferroPTosis. Expand
OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3
The findings revealed that the DNA binding capacity of IRF3 in the innate immune signaling pathway was modulated by atypical K6-linked ubiquitination and deubiquitination process, which was regulated by the deUBiquitinase OTUD1. Expand
The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.
It is shown that the nuclear matrix protein SAFA functions as a nuclear viral dsRNA sensor and trans-activator to bridge innate sensing with chromatin remodeling and potentiate robust antiviral responses. Expand
Transcriptional Regulation of Natural Killer Cell Development and Functions
Recent advances in the understandings of TFs involved in the regulation of NK cell development, maturation, and effector function are summarized, in the aspects of their mechanisms, potential targets, and functions. Expand
Vascular Reactivity Screen of Chinese Medicine Danhong Injection Identifies Danshensu as a NO-Independent but PGI2-Mediated Relaxation Factor
Results revealed a previously unknown endothelium-dependent vasorelaxation mechanism by danshensu and together with previously reported activity on ion channels of vascular smooth muscle cells, demonstrated that its dual actions contribute to a multicomponent Chinese herbal medicine that synergistically targets different pathways to achieve its well-documented cardiovascular protective effects. Expand
miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis
Stable overexpression of miR-615-3p was sufficient to promote cell motility in vitro, and pulmonary metastasis in vivo, accompanied by the reduced expression of epithelial markers and the increased levels of mesenchymal markers. Expand
LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress.
  • Shuai Xu, Yuanyu Wang, +9 authors Xiaoxiao Yang
  • Medicine, Chemistry
  • Biomedicine & pharmacotherapy = Biomedecine…
  • 23 December 2019
It is demonstrated that LSZ reduces heart failure by reducing production of reactive oxygen species and inhibiting inflammation/apoptosis and the potential application of LSZ for heart failure treatment is suggested. Expand
MicroRNA‐182 exacerbates blood‐brain barrier (BBB) disruption by downregulating the mTOR/FOXO1 pathway in cerebral ischemia
It is demonstrated for the first time that cerebral ischemia leads to a significant progressive increase in miR‐182 after pMCAO, and bEnd.3 cells are the primary target cells of miR •182, and the mechanism by which microRNAs regulate BBB integrity is explored. Expand
Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes.
Findings indicate that the highly expressed miR-204-5p plays a prominent role in safeguarding the kidneys against common causes of chronic renal injury. Expand
Excess salt intake promotes M1 microglia polarization via a p38/MAPK/AR-dependent pathway after cerebral ischemia in mice.
In mice, surplus dietary salt promotes polarization in pro-inflammatory M1 microglia by upregulating the expression of the AR protein via p38/MAPK, thereby exacerbating the development of ischemia stroke. Expand