Graph orientation is a fundamental problem in graph theory that has recently arisen in the study of signaling-regulatory pathways in protein networks. Given a graph and a list of orderedâ€¦ (More)

In a network orientation problem, one is given a mixed graph, consisting of directed and undirected edges, and a set of source-target vertex pairs. The goal is to orient the undirected edges so thatâ€¦ (More)

ANAT is a graphical, Cytoscape-based tool for the inference of protein networks that underlie a process of interest. The ANAT tool allows the user to perform network reconstruction under severalâ€¦ (More)

In a network orientation problem one is given a mixed graph, consisting of directed and undirected edges, and a set of source-target vertex pairs. The goal is to orient the undirected edges so that aâ€¦ (More)

UNLABELLED
The graph orientation problem calls for orienting the edges of a graph so as to maximize the number of pre-specified source-target vertex pairs that admit a directed path from the sourceâ€¦ (More)

Personalized therapy is a major goal of modern oncology, as patient responses vary greatly even within a histologically defined cancer subtype. This is especially true in acute myeloid leukemiaâ€¦ (More)

We introduce a graph orientation problem arising in the study of biological networks. Given an undirected graph and a list of ordered source-target vertex pairs, the goal is to orient the graph suchâ€¦ (More)

We present a computational strategy to simulate drug treatment in a personalized setting. The method is based on integrating patient mutation and differential expression data with a protein-proteinâ€¦ (More)

Graph orientation is a fundamental problem in graph theory that has recently arisen in the study of signaling-regulatory pathways in protein networks. Given a graph and a list of source-target vertexâ€¦ (More)