Dana R. Pierce

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The effect of alcohol on body and brain growth of the neonatal rat was examined. An artificial rearing procedure was used to administer a milk formula containing 2.8% alcohol to rat pups during days 4-10 postpartum. Mean blood alcohol levels taken at hourly intervals between feelings at the end of the second day of exposure ranged between 151 and 163 mg/dl.(More)
Neonatal rats were exposed to 6.6 g/kg of alcohol each day between postnatal days 4 and 10 while artificial-rearing procedures were used, in a manner which produced high peak and low trough blood alcohol concentrations each day. Gastrostomy controls were reared artificially with maltose/dextrin isocalorically substituted for alcohol in the milk formula, and(More)
OBJECTIVE To compile and assess the English-language literature on drug-induced nightmares, excluding nightmares secondary to drug withdrawal or drug-associated night terrors. DATA SOURCES Published articles, letters, case reports, and abstracts in English were identified by MEDLINE (1966-May 1998) searches using the search term nightmares, chemically(More)
Fetal alcohol syndrome (FAS) is now well documented, but factors that affect the severity of the accompanying central nervous system damage are still not well understood. In a series of experiments, artificially reared neonatal rats were exposed to alcohol during postnatal days 4-10 (during the brain growth spurt of the rat) to evaluate the consequences of(More)
To investigate whether or not blood alcohol concentration during the brain growth spurt has an influence on the permanency of alcohol-induced central nervous system damage, an artificial rearing technique was used to administer a daily dose of alcohol (6.6 g/kg/day) to neonatal rats during postnatal days 4 to 10. The alcohol was administered either in a(More)
A dose of 6.6 g/kg of alcohol, delivered in 12 equally-spaced fractions each 24 hours via an artificial rearing procedure during postnatal days 4-10, produced mean blood alcohol concentrations (BACs) that were low (46.6 mg/dl), but stable with time. This relatively constant alcohol exposure did not limit brain growth in neonatal rats when measured on(More)
Adult rats, exposed to ethanol in utero exhibit aberrant mossy fiber-like Timm staining in the distal infrapyramidal region of the hippocampus at midtemporal levels. The present study utilized the anterograde transport of HRP to verify that the aberrant pattern of Timm staining represented a terminal field of the dentate granule cells. One or more(More)
Alcohol was administered in different doses to groups of neonatal rat pups from postnatal days 4-10 using an artificial rearing technique. Blood alcohol concentrations (BACs) were monitored in pups on postnatal day 6. Brain weights were measured on postnatal day 10 and the extent of microencephaly was correlated with dose and BAC. Doses of 7.4 g/kg/day and(More)
Neonatal rats were exposed to alcohol during a period of brain development equivalent to part of the human third trimester. Rat pups were fed a milk formula containing either alcohol (9.8 g/kg/day) or isocaloric maltose/dextrin using artificial rearing techniques from postnatal days 4-10. Blood alcohol concentrations reached 345.8 +/- 15.6 mg/dl on(More)
Average rates of polypeptide chain elongation were determined in placental explants of first trimester and term placentas from both normal and diabetic human pregnancies. Average ribosome half-transit times were determined by measuring the kinetics of transfer of labeled polypeptides from polysomal-bound to released polypeptides. The average half-transit(More)