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Qualitative Assessment of a Multi-Scale, Compartmental PBM-DEM Model of a Continuous Twin-Screw Wet Granulation Process
Wet granulation processes play a crucial role in solid oral dosage manufacturing processes. However, they are often designed empirically with poor efficiency. To implement quality-by-design, a moreExpand
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Multi-dimensional population balance model development and validation for a twin screw granulation process
In this study, a novel multi-component population balance model (PBM) for the twin-screw granulation (TSG) process was developed, taking into account the rate processes of aggregation, breakage,Expand
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A multi-scale, mechanistic model of a wet granulation process using a novel bi-directional PBM–DEM coupling algorithm
Abstract In this study, a novel mechanistic model for a wet granulation process is presented, combining the techniques of population balance modeling and discrete element methods to predict criticalExpand
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A reduced order PBM–ANN model of a multi-scale PBM–DEM description of a wet granulation process
Abstract Wet granulation is a particle design process, often used in the pharmaceutical, consumer product, food, and fertilizer industries. A better process understanding is needed to improve processExpand
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A comparison of model order reduction techniques for a four-dimensional population balance model describing multi-component wet granulation processes
Abstract Three-dimensional (3-D) population balance equations are often used to model wet granulation processes, simulating distributions in particle size, liquid binder content, and porosity. InExpand
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Multi-scale modeling of granulation processes: Bi-directional coupling of PBM with DEM via collision frequencies
Abstract Wet granulation is a complex particle design process often operated inefficiently in industrial applications. Enhanced process understanding is required to facilitate design, control, andExpand
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Population Balance Model Validation and Predictionof CQAs for Continuous Milling Processes: toward QbDin Pharmaceutical Drug Product Manufacturing
Continuous tablet manufacturing has been investigated for its potential advantages (e.g., cost, efficiency, and controllability) over more conventional batch processes. One avenue for tabletExpand
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Model Order Reduction of a Multi-scale PBM-DEM Description of a Wet Granulation Process via ANN
Abstract Wet granulation is a particle design process, often used in the pharmaceutical, consumer product, food, and fertilizer industries. A better process understanding is needed to improve processExpand
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Simulation of population balance model-based particulate processes via parallel and distributed computing
TLDR
This paper describes how distributed computing systems may be leveraged to execute PBM-based simulations thus achieving time savings, using MATLAB's Distributed Computing Toolbox. Expand
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A Multi-Scale Hybrid CFD-DEM-PBM Description of a Fluid-Bed Granulation Process
In this study, a hybrid multi-scale model has been developed for a continuous fluid bed wet granulation process by dynamically coupling computational fluid dynamics (CFD) with a discrete elementExpand
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