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Whereas the expression patterns and kinetic properties of the rice (Oryza sativa) phosphate transporter gene OsPht1; 6 (OsPT6) are well documented, little is known about the biological functions of this gene. The aim of this study was to investigate the roles of OsPT6 in inorganic phosphate (Pi) acquisition and mobilization, and examine its potential to(More)
AIM To investigate the effects of the WWOX gene on the human hepatic carcinoma cell line SMMC-7721. METHODS Full-length WWOX cDNA was amplified from normal human liver tissues. Full-length cDNA was subcloned into pEGFP-N1, a eukaryotic expression vector. After introduction of the WWOX gene into cancer cells using liposomes, the WWOX protein level in the(More)
OBJECTIVE The purpose of this study was to demonstrate omentin-1 levels in serum and synovial fluid (SF) of patients with knee osteoarthritis (OA) and to investigate their correlation with radiographic disease severity. METHODS One hundred and ninety-seven patients with OA and 65 sex- and age-matched healthy controls were enrolled in this study. The(More)
The primary effect of the endoplasmic reticulum (ER) stress response or unfolded protein response (UPR) is to reduce the load of unfolded protein and promote survival. However, prolonged and severe ER stress leads to tissue injury and serious diseases. Thus, it is important to identify drugs that can attenuate ER stress for the treatment of diseases.(More)
OBJECTIVE To investigate the correlation between Chlamydia pneumonia (Cpn) infection and chronic obstructive pulmonary disease (COPD). METHODS 82 patients with acute exacerbation COPD (AE-COPD) or stabilized COPD patients at outpatient visits, in the People's Hospital of Jiangyin city from Aug. 2010 to May 2012, together with 46 cases having stationary(More)
OBJECTIVE To explore the relationship of telomerase RNA component (hTERC) and the telomerase reverse transcriptase (hTERT) with telomerase activity in the marrow hemopoietic stem cells of children with aplastic anemia (AA). METHODS Fifty-two children with chronic AA, 13 children with acute AA and 21 normal controls were enrolled in the study. Telomerase(More)
This phase II study is performed to evaluate the safety, efficacy and tolerability of carboplatin combined with weekly docetaxel in patients with advanced non-small cell lung cancer (NSCLC). All patients were treated with the combination of docetaxel 35 mg/m2 by IV infusion over 30–60 min weekly, on days 1, 8, and 15, for 3 weeks followed by 1 week of rest,(More)
OBJECTIVE To investigate the change in telomere length and TERC and TERT mutations in peripheral blood leukocytes of children with chronic aplastic anemia (CAA). METHODS Sixty-nine children with CAA were divided into untreated group (n=24) who did not receive immunosuppressive therapy (IST), response group (n=36) who showed response to IST, and(More)
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