Rats were treated with kainic acid (KA) i.v. to produce increasingly severe limbic seizures that were monitored with a behavioral rating scale. At various times after the induction of seizures, the animals; blood-brain barriers (B-BB) were studied with alpha-[14C]aminoisobutyric acid ([14C]AIBA) autoradiography. Using optical density ratios, a coefficient… (More)
Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma ratio of its precursor tryptophan over… (More)
Although an association of psychiatric symptoms with vitamin B12 deficiency is well accepted, the incidence and nature of these symptoms is not established. To help illuminate the natural history of this illness we review the literature regarding psychopathology associated with B12 deficiency and examine 15 cases, including one of our own, that meet… (More)
Twenty patients with panic attacks and ten controls were given a standardised interview about thoughts occurring during times of anxiety or panic attacks. The interviewer was blind to the subject's diagnosis. The 20 panic patients underwent a psychophysiological test battery which included a cold pressor test, mental arithmetic task, and 5.5% CO2… (More)
A case of fibrosarcoma with metastases to the brain is presented with a review of the pertinent literature. This review demonstrates that the incidence of brain metastases in patients with sarcoma is probably higher than previously indicated.
A dural mesenchymal chondrosarcoma is reported in a 19-year-old man. This tumor had features of angioblastic meningioma (meningeal hemangiopericytoma), by light microscopy. However, ultrastructurally this tumor could be distinguished from angioblastic meningioma, and its similarity to extracranial mesenchymal chondrosarcoma was confirmed.
Some patients who take tricyclic antidepressants (TCAs) develop delirium. Charts were reviewed of 125 inpatients whose TCA plasma levels had been assayed. Delirium was documented in 10 cases. The occurrence of delirium was statistically related to age, race, and loge plasma TCA levels.
In recent years computer applications have increased in their computational complexity. The industry-wide usage of performance benchmarks, such as SPECmarks, forces processor designers to pay particular attention to implementation of the oating point unit, or FPU. Special purpose applications, such as high performance graphics rendering systems, have placed… (More)
UNLABELLED 1. This study was undertaken to evaluate the relationship between clinical aspects of primary degenerative dementia and suppression or non-suppression in the dexamethasone suppression test. 2. We studied 34 male patients with primary degenerative dementia (as diagnosed by DSM-III criteria). Dexamethasone 1 mg p.o. was administered at 11:00 PM and… (More)