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PURPOSE To investigate expression, regulation, potential role and targets of miR-195 and miR-497 in breast cancer. EXPERIMENTAL DESIGN The expression patterns of miR-195 and miR-497 were initially examined in breast cancer tissues and cell lines by Northern blotting and quantitative real-time PCR. Combined bisulfite restriction analysis and bisulfite(More)
An integrated inventory of atmospheric antimony (Sb) emissions from anthropogenic activities in China is compiled for the years 2005-2009. Emissions are estimated for all major anthropogenic sources for the first time. We estimate that the national emissions of antimony are 818 metric tons (t) in 2009, with the largest contribution from coal combustion at(More)
Cyst expansion in polycystic kidney disease (PKD) involves progressive fluid accumulation, which is believed to require chloride transport by the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Herein is reported that small-molecule CFTR inhibitors of the thiazolidinone and glycine hydrazide classes slow cyst expansion in in vitro and in(More)
Web applications tend to evolve quickly, resulting in errors and failures in test automation scripts that exercise them. Repairing such scripts to work on the updated application is essential for maintaining the quality of the test suite. Updating such scripts manually is a time consuming task, which is often difficult and is prone to errors if not(More)
Thirteen pure strains that possessed high methyl red (MR)-decolorizing ability were isolated from dye-contaminated water. Each isolate was identified by 16S rDNA sequencing. The results reveal that all of the isolated strains were facultative anaerobic bacteria. Two novel bacterial consortia (AE and AN), which could decolorize MR under aerobic and anaerobic(More)
BACKGROUND A recent epidemic of melamine contamination of baby formula in China has been associated with the development of urinary tract stones, though the clinical manifestations and predisposing factors are incompletely delineated. METHODS We administered a questionnaire to the parents of children 36 months of age or younger who were being screened for(More)
The P53 tumor suppressor pathway plays an important role in cancer development. The auto-regulatory feedback mechanism of the P53 and MDM2 expression is critical in keeping proper tumor suppressor function of this pathway. This study examined the effect of P53 Arg72Pro variants on transactivation of polymorphic MDM2 promoter (T309G) and their associations(More)
Aquaporin-8 (AQP8) is a water-transporting protein expressed in organs of the mammalian gastrointestinal tract (salivary gland, liver, pancreas, small intestine, and colon) and in the testes, heart, kidney, and airways. We studied the phenotype of AQP8-null mice, and mice lacking AQP8, together with AQP1 or AQP5. AQP8-knockout mice lacked detectable AQP8(More)
Recent reports suggest the expression of aquaporin (AQP)-type water channels in mitochondria from liver (AQP8) (Calamita, G., Ferri, D., Gena, P., Liquori, G. E., Cavalier, A., Thomas, D., and Svelto, M. (2005) J. Biol. Chem. 280, 17149-17153) and brain (AQP9) (Amiry-Moghaddam, M., Lindland, H., Zelenin, S., Roberg, B. A., Gundersen, B. B., Petersen, P.,(More)